ID   RPSB_MYXXA              Reviewed;         246 AA.
AC   P19433;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=RNA polymerase sigma-B factor;
GN   Name=sigB;
OS   Myxococcus xanthus.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=34;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FB / DZF1;
RX   PubMed=2121605; DOI=10.1101/gad.4.8.1396;
RA   Apelian D., Inouye S.;
RT   "Development-specific sigma-factor essential for late-stage differentiation
RT   of Myxococcus xanthus.";
RL   Genes Dev. 4:1396-1403(1990).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RX   PubMed=1597408; DOI=10.1128/jb.174.12.3843-3849.1992;
RA   Lonetto M., Gribskov M., Gross C.A.;
RT   "The sigma 70 family: sequence conservation and evolutionary
RT   relationships.";
RL   J. Bacteriol. 174:3843-3849(1992).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. This sigma factor is essential for late-stage differentiation
CC       of M.xanthus.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
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DR   EMBL; X55500; CAA39117.1; ALT_SEQ; Genomic_DNA.
DR   PIR; A36672; A36672.
DR   PIR; T10127; T10127.
DR   AlphaFoldDB; P19433; -.
DR   SMR; P19433; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 1.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sigma factor; Transcription; Transcription regulation.
FT   CHAIN           1..246
FT                   /note="RNA polymerase sigma-B factor"
FT                   /id="PRO_0000093967"
FT   DNA_BIND        201..220
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOTIF           25..38
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   246 AA;  27841 MW;  6E3B016697E4849B CRC64;
     MVTANLRFVV KVAYEYRSYG IKMSDLIQEG NIGLMKAVQK FDPDKGIRLI SYAVWWIRAY
     IQNYILKSWS LVKLGTTQAH GKLFFSLART RRELEKFGSG DAAVNVDDIA RRLHVKPGEV
     REMEQRMGGR DLSLDAPMGE DGGNSHVDFV VSAAAPQDDE FADKEEAGLI NARVRAALMR
     LDPREPFIIE QRVMNERPMT LKELGEHFGF SRERARQLEI RAKDKLKSEL AALMAEVDPE
     AVAAQQ