ID   RPSC_NOSS1              Reviewed;         416 AA.
AC   Q03066;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=RNA polymerase sigma-C factor;
GN   Name=sigC; OrderedLocusNames=all1692;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1385387; DOI=10.1128/jb.174.22.7273-7282.1992;
RA   Brahamsha B., Haselkorn R.;
RT   "Identification of multiple RNA polymerase sigma factor homologs in the
RT   cyanobacterium Anabaena sp. strain PCC 7120: cloning, expression, and
RT   inactivation of the sigB and sigC genes.";
RL   J. Bacteriol. 174:7273-7282(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M95759; AAA22047.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB78058.1; -; Genomic_DNA.
DR   PIR; AF2017; AF2017.
DR   PIR; C47017; C47017.
DR   RefSeq; WP_010995861.1; NZ_RSCN01000013.1.
DR   AlphaFoldDB; Q03066; -.
DR   SMR; Q03066; -.
DR   STRING; 103690.17135512; -.
DR   EnsemblBacteria; BAB78058; BAB78058; BAB78058.
DR   KEGG; ana:all1692; -.
DR   eggNOG; COG0568; Bacteria.
DR   OMA; KKYQQRG; -.
DR   OrthoDB; 1565734at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR017848; RNA_pol_sigma_RpoD_cyanobac.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02997; Sig70-cyanoRpoD; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Sigma factor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..416
FT                   /note="RNA polymerase sigma-C factor"
FT                   /id="PRO_0000093936"
FT   DNA_BIND        374..393
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOTIF           205..218
FT                   /note="Polymerase core binding"
FT   CONFLICT        52
FT                   /note="A -> R (in Ref. 1; AAA22047)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   416 AA;  47374 MW;  0467340EA278964F CRC64;
     MPATSFYADA AYNTQKSRQA LDPDIAIDDS DLSVDEIQEL EIAAADPATF GASANRRSTD
     LVRLYLQEIG RVRLLGRDEE VSEAQKVQRY LKLRIVLANA VKQGDEVATP YLHLIEVQER
     LASELGHRPS LERWAATAGI NLCDLKPILS EGKRRWAEIA KMTVEELEKM QSQGLQSKEH
     MIKANLRLVV SVAKKYQNRG LELLDLVQEG TLGLERAVEK FDPTKGYRFS TYAYWWIRQG
     ITRAIATSSR TIRLPVHITE KLNKIKKAQR KIAQEKGRTP TLEDLAIELD MTPTQVREVL
     LRVPRSVSLE TKVGKDKDTE LGELLETDGV TPEEMLMRES LQRDLQHLLA DLTSRERDVI
     LMRFGLADGH PYSLAEIGRA LDLSRERVRQ IESKALQKLR QPKRRNLIRD YLESLS