AB51G_ORYSJ
ID AB51G_ORYSJ Reviewed; 1441 AA.
AC Q8S628; Q0IYJ0; Q8GU94;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=ABC transporter G family member 51 {ECO:0000305};
DE Short=OsABCG51 {ECO:0000305};
DE AltName: Full=Pleiotropic drug resistance protein 13 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
DE Short=OsPDR13 {ECO:0000303|PubMed:16506311};
GN Name=ABCG51 {ECO:0000305};
GN Synonyms=PDR13 {ECO:0000303|PubMed:12644668, ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os10g0205500 {ECO:0000312|EMBL:BAF26225.1},
GN LOC_Os10g13830; ORFNames=OSJNBb0048O22.8 {ECO:0000312|EMBL:AAM18755.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12644668; DOI=10.1104/pp.102.014720;
RA Jasinski M., Ducos E., Martinoia E., Boutry M.;
RT "The ATP-binding cassette transporters: structure, function, and gene
RT family comparison between rice and Arabidopsis.";
RL Plant Physiol. 131:1169-1177(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12791992; DOI=10.1126/science.1083523;
RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP52728.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF26225.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ535042; CAD59564.1; -; Genomic_DNA.
DR EMBL; AC099325; AAM18755.1; -; Genomic_DNA.
DR EMBL; DP000086; AAP52728.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008216; BAF26225.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q8S628; -.
DR SMR; Q8S628; -.
DR STRING; 4530.OS10T0205500-01; -.
DR PRIDE; Q8S628; -.
DR InParanoid; Q8S628; -.
DR Proteomes; UP000000763; Chromosome 10.
DR Proteomes; UP000059680; Chromosome 10.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1441
FT /note="ABC transporter G family member 51"
FT /id="PRO_0000234651"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 615..635
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 668..688
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 751..771
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1184..1204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1214..1234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1271..1291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1300..1320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1330..1350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1355..1375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1413..1433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 154..428
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 505..718
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 838..1090
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1163..1380
FT /note="ABC transmembrane type-2 2"
FT REGION 52..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 187..194
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 883..890
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 1441
FT /note="S -> R (in Ref. 1; CAD59564)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1441 AA; 161591 MW; CC1D291BB890C6EC CRC64;
MAFAAGGIDH HVAVDVEGEE ESRRRAVAEE ADLLWAAFER LPSAKRRSHA VVLPDPDGLG
GGDGGGRGEG QLVDVRKLDR PGLQRVLRHA LATSELDNAN LLHGIKARFD AVGLEVPRVE
VRFQNLTVST DVHVGRRALP TLVNYVHDIA ERILISSHLL RPDKHKLVIL DDVSGVIKPG
RMTLLLGPPA SGKSTLLLAL ADKLDSQLKK SGEVAYNGMA LDQFCVQRTS AYISQTDNHI
GELTVRETLD FAAKCQGASE NWQECLKELV NLEKERGIRP SPEIDAFMKT ASFRREKHNL
VSDYVLRVLG LDICADTPVG SDMERGVSGG QKKRVTTGEM IIGPRKTLLM DEISTGLDSS
TTFQIVNCMR NFVHEMEATV LMSLLQPAPE TFELFDDLIL LSEGKIIYQG PIKHVVDYFK
SLGFSLPPRK GIADFLQEVT SKKDQAQYWS DQSKQHIFVS ASEMAAVFKE SQYGTYLEAN
LSSSCGNKDS ALVLPRSKFA VPKFSLVRAC FARELILISR NRFLYTFRTC QVAFVGIITS
TLFLRTRLHP VDEQNGNLYL ACLFFGLVHM MFNGFTEMTM TISRLPVFYK QRDNFFHPAW
AFSLPNWILR IPYSFIEAVV WSCVVYYTVG FAPTVDRFFR FMLLLFSIHQ MALGLFRMMG
AIARDMTIAS TFGSAVLLAI FLLGGFVVPK GFIKPWWDWA YWISPLMYAQ RAVSVNEFSA
SRWSKVSVSG NMTVGTNILI SHSLPTDDHW FWIGVGVLLA YSIFFNIMFT LALAFLNPLR
KPQSMVPSDA GDGRDVHINT DSNKNTIGEI FENNDGFEGQ TECKSKKGMI LPFQPLTMTF
HNVNYYVNMP KEMQAKGVPE KRLQLLSEVS GIFRPRVLTA LVGASGSGKT TLMDVLAGRK
TGGYIEGDIR ISGHKKEQRT FARIAGYVEQ NDIHSPQVTV EESLWFSSTL RLPNDISRET
RHAFVEEVMA LVELDQIRYA LVGKQGLTGL STEQRKRLTI AVELVANPSI IFMDEPTSGL
DARAAAIVMR TVRNTVDTGR TVVCTIHQPS IDIFEAFDEL LLMKRGGRVI YGGSLGVNSV
DMINYFQGIP RVVPITEGYN PATWMLEVTT QASEERLGID FATVYKNSYQ FRNVENLIVE
LSIPASGTEP LKFSSEFSQN RLTQFMVCLR KQSLVYWRSP EYNVVRLFFT SVAAIIFGSI
FWNVGMKRES TEDILLLMGA LYAACLFLGV NNASSVQPVV SVERTVYYRE RAANMYSSFP
YAAAQVYHGL VEIPYIAVQT LIFGLITYFM VNYERNIRKL VLYLIYMFLT FTYFTFYGMV
AVGLTPTQHM ASVVSSAFYS LWNLLSGFLI PQSRIPGWWI WFYYICPVAW TLRGVITSQL
GDVDTRIVGP GFDGTVHEFL QQNLGFEQGM TGATVAVLVA FSVFFFSIYA ISIKMINFQR
S
