ID   RPSW_STRCO              Reviewed;         280 AA.
AC   P17211;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 138.
DE   RecName: Full=RNA polymerase sigma factor WhiG;
GN   Name=whiG; OrderedLocusNames=SCO5621; ORFNames=SC2E1.38;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=2507166; DOI=10.1016/0092-8674(89)90876-3;
RA   Chater K.F., Bruton C.J., Plaskitt K.A., Buttner M.J., Mendez C.,
RA   Helmann J.D.;
RT   "The developmental fate of S. coelicolor hyphae depends upon a gene product
RT   homologous with the motility sigma factor of B. subtilis.";
RL   Cell 59:133-143(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released.
CC   -!- FUNCTION: The level of this sigma factor may be crucial in determining
CC       the developmental fate of hyphae.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
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DR   EMBL; J03169; AAA26828.1; -; Genomic_DNA.
DR   EMBL; AL939124; CAA19413.1; -; Genomic_DNA.
DR   PIR; A33332; A33332.
DR   RefSeq; NP_629755.1; NC_003888.3.
DR   RefSeq; WP_003973389.1; NZ_VNID01000034.1.
DR   AlphaFoldDB; P17211; -.
DR   SMR; P17211; -.
DR   STRING; 100226.SCO5621; -.
DR   GeneID; 1101062; -.
DR   KEGG; sco:SCO5621; -.
DR   PATRIC; fig|100226.15.peg.5710; -.
DR   eggNOG; COG1191; Bacteria.
DR   HOGENOM; CLU_014793_8_1_11; -.
DR   InParanoid; P17211; -.
DR   OMA; IKFETYA; -.
DR   PhylomeDB; P17211; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR012845; RNA_pol_sigma_FliA_WhiG.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PIRSF; PIRSF000770; RNA_pol_sigma-SigE/K; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02479; FliA_WhiG; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Sigma factor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..280
FT                   /note="RNA polymerase sigma factor WhiG"
FT                   /id="PRO_0000093989"
FT   DNA_BIND        246..265
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           77..90
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   280 AA;  30917 MW;  BBF5CCF5C6F5D664 CRC64;
     MPQHTSGSDR AAIPPAARDG GSVRPPAPST LDELWRSYKT TGDERLREQL ILHYSPLVKY
     VAGRVSVGLP PNVEQADFVS SGVFGLIDAI EKFDVDREIK FETYAITRIR GAMIDELRAL
     DWIPRSVRQK ARNVERAYAT LEARLRRTPS ESEVAVEMGI AVEDLHAVFS QLSLANVVAL
     EELLHAGGEG GGRLSLMDTL EDTAADNPVE VAEDRELRRL LARAINTLPE REKTVVTLYY
     YEGLTLAEIG NVLGVTESRV SQIHTKSVLQ LRAKLAGFGR