RPTOR_DICDI
ID RPTOR_DICDI Reviewed; 1509 AA.
AC Q55BR7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Protein raptor homolog;
GN Name=raptor; ORFNames=DDB_G0270398;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION IN A TORC1 COMPLEX.
RX PubMed=16079174; DOI=10.1091/mbc.e05-04-0342;
RA Lee S., Comer F.I., Sasaki A., McLeod I.X., Duong Y., Okumura K.,
RA Yates J.R. III, Parent C.A., Firtel R.A.;
RT "TOR complex 2 integrates cell movement during chemotaxis and signal relay
RT in Dictyostelium.";
RL Mol. Biol. Cell 16:4572-4583(2005).
CC -!- SUBUNIT: Part of a complex, TORC1, consisting of tor, raptor and lst8.
CC {ECO:0000269|PubMed:16079174}.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72549.1; -; Genomic_DNA.
DR RefSeq; XP_646764.1; XM_641672.1.
DR AlphaFoldDB; Q55BR7; -.
DR SMR; Q55BR7; -.
DR STRING; 44689.DDB0234064; -.
DR PaxDb; Q55BR7; -.
DR EnsemblProtists; EAL72549; EAL72549; DDB_G0270398.
DR GeneID; 8617737; -.
DR KEGG; ddi:DDB_G0270398; -.
DR dictyBase; DDB_G0270398; raptor.
DR eggNOG; KOG1517; Eukaryota.
DR HOGENOM; CLU_001136_3_1_1; -.
DR InParanoid; Q55BR7; -.
DR OMA; QWSCLCL; -.
DR PhylomeDB; Q55BR7; -.
DR Reactome; R-DDI-1632852; Macroautophagy.
DR Reactome; R-DDI-165159; MTOR signalling.
DR Reactome; R-DDI-166208; mTORC1-mediated signalling.
DR Reactome; R-DDI-3371571; HSF1-dependent transactivation.
DR Reactome; R-DDI-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR Reactome; R-DDI-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-DDI-8943724; Regulation of PTEN gene transcription.
DR Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR PRO; PR:Q55BR7; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005776; C:autophagosome; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031931; C:TORC1 complex; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:1903666; P:positive regulation of asexual reproduction; IMP:dictyBase.
DR GO; GO:0030307; P:positive regulation of cell growth; IBA:GO_Central.
DR GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR GO; GO:0031929; P:TOR signaling; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12848; PTHR12848; 1.
DR Pfam; PF14538; Raptor_N; 1.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1509
FT /note="Protein raptor homolog"
FT /id="PRO_0000368234"
FT REPEAT 1184..1225
FT /note="WD 1"
FT REPEAT 1229..1270
FT /note="WD 2"
FT REPEAT 1284..1328
FT /note="WD 3"
FT REPEAT 1332..1371
FT /note="WD 4"
FT REPEAT 1377..1418
FT /note="WD 5"
FT REPEAT 1420..1460
FT /note="WD 6"
FT REPEAT 1468..1507
FT /note="WD 7"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1509 AA; 167888 MW; 57C6706C874678DF CRC64;
MDKSYNFSSS NLANSSGLHN SINSNNVNGV NNINNNNNNN NNNNNNNNNN NNNENVNNHN
NVSNISNTHQ QAKKKEKYNN NNNKNKPFFG EERHKDNATP DVQKTKIAKW RMRERMKTVS
VALVLCLNIG VDPPDVIKTF PCARMECWFD PSTQPPQKAL DLIGKTLQAQ YEKWQSKARY
KQSLDPTVEE VKKLCLSLRR NAKDERVLFH YNGHGVPKPT TNGEIWVFNR NFTQYIPLSI
YELQTWMGTP SIYVFDCSAA GLIINWFNQF AEQRDKELER FSGNNQNNNQ NNNQNSNQNN
QNNTTNSTNG NTNGNNQQNN NNSNNNSSNN SNTNSPNMGS SNSVNNNQSG SSSSSSHQRD
CILLAACSAN EILPMNPDFP ADMFTACLTT PIRIALRWFC SHSILTGITA DMLDKIPGNL
SSRRTPLGEL NWIFTAVTDT IAWNVLPRHL FQKLFRQDLL VASLFRNYLL AERIMRSANC
TPISCPRLPP TYQHAMWQAW DLAVDLVISQ LPTLLADPNA EFKSSPFFTE QLTAFEVWLE
FGSEHKDPPA QLPIVLQVLL SQAHRLRALV LLGKFLDLGP WAVNLALCVG IFPYVLKLLQ
SPAGDLRHIL VFIWAKILAL DKSCQLDLVK ENGHAYFISV LSSPQIPADQ RTMSAFVLST
ICNNCRPGQN ACLIGNLLPI CLSQLNDPDP MVRRWMILCM AKMWENFEEA KWAAIKENAH
EKLCLLLTDV SPEVRASAVV ALGELIGGAE GSEQRTNIEL NLALTLAVIT ADCSPMVRKE
LVISLSRIVS SYESNFVQVA QEIAQEERLR AVLEAKRLEE SRKSKKRASV PKISDADHLN
NNSDLYGNGS QSSVYGCLWK IILNLCTDPF DQVANRAQSI VKRISSKFSM EELMSHNLIN
RTNFNFNNLN GSMNGLNSSG SGFLNSSNGN LGASMNGSNL NSSNNNLGGS SGGGFGLNNS
NSSIRNTFVN ISRITNRDPR SPTKTKLGNQ RSPILTSSTN NVGTNLNGNQ LNLNNNNINN
GNINNNNNNN SSINNNGNNI NNNGNGNNNN INNNNGLGNQ LANTFQSLSL SSGLGGNKTN
KMSQSISSMN SSSQSLQNDF LMVSDSMPFE EDELYSDYYE WSCNYFSKPM MQSTGEDFES
FESIEKKWKR QRNEMIIQES KEAVQNIIQQ PPKSFSQMTI FAEPNGQPIS HLQFHPFDNI
LVVSDGLENI SVWNYDDGQR INTFNNCNMS GTRITSMKLV NDYDPSMIIT AADDGVVRIW
RGYESNDTLK MVSSWRAFPE FATTGNDPIG RLVLDWKGDS GLVLVSGETP DSPKIRIWDV
ERELGVQDIF IGTESVVTCM ANEKRGPLFS AGFSDGLVKL FDQRIPGKYS CVSTLTEHKS
YIVNVSMPAS LGGKTVVSGS STGEIKFWQH SYECSSTTIH NNDVISSFSV HEYAPLIACG
SQNQRIKIMN FTGEDVCTIR YHDGFLGQRI GPVSCVAFHP YNILMGAGAT DSIISIYNGD
SKSKSNVDW
