ID   RPW81_ARATH             Reviewed;         148 AA.
AC   Q9C5Z7;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Protein RESISTANCE TO POWDERY MILDEW 8.1 {ECO:0000303|PubMed:11141561};
DE            Short=AtRPW8.1 {ECO:0000303|PubMed:15155802};
GN   Name=RPW8.1 {ECO:0000303|PubMed:11141561};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:AAK09266.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, MISCELLANEOUS, GENE FAMILY,
RP   AND NOMENCLATURE.
RC   STRAIN=cv. Ms-0;
RX   PubMed=11141561; DOI=10.1126/science.291.5501.118;
RA   Xiao S., Ellwood S., Calis O., Patrick E., Li T., Coleman M., Turner J.G.;
RT   "Broad-spectrum mildew resistance in Arabidopsis thaliana mediated by
RT   RPW8.";
RL   Science 291:118-120(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND REVIEW ON GENETIC VARIATIONS.
RX   PubMed=19140981; DOI=10.1111/j.1365-294x.2008.03960.x;
RA   Jorgensen T.H., Emerson B.C.;
RT   "Functional variation in a disease resistance gene in populations of
RT   Arabidopsis thaliana.";
RL   Mol. Ecol. 17:4912-4923(2008).
RN   [3]
RP   FUNCTION, MISCELLANEOUS, CAUTION, INDUCTION BY ERYSIPHE CICHORACEARUM, AND
RP   GENE FAMILY.
RX   PubMed=15155802; DOI=10.1093/molbev/msh165;
RA   Xiao S., Emerson B., Ratanasut K., Patrick E., O'Neill C., Bancroft I.,
RA   Turner J.G.;
RT   "Origin and maintenance of a broad-spectrum disease resistance locus in
RT   Arabidopsis.";
RL   Mol. Biol. Evol. 21:1661-1672(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=17565954; DOI=10.1534/genetics.107.070565;
RA   Orgil U., Araki H., Tangchaiburana S., Berkey R., Xiao S.;
RT   "Intraspecific genetic variations, fitness cost and benefit of RPW8, a
RT   disease resistance locus in Arabidopsis thaliana.";
RL   Genetics 176:2317-2333(2007).
RN   [5]
RP   INDUCTION BY BENEFICIAL MICROBES.
RC   STRAIN=cv. Ms-0;
RX   PubMed=22942755; DOI=10.3390/ijms13079110;
RA   Saenz-Mata J., Jimenez-Bremont J.F.;
RT   "HR4 gene is induced in the Arabidopsis-trichoderma atroviride beneficial
RT   interaction.";
RL   Int. J. Mol. Sci. 13:9110-9128(2012).
CC   -!- FUNCTION: Disease resistance (R) protein that induces localized,
CC       salicylic acid-dependent defenses (PubMed:11141561). Confers resistance
CC       to powdery mildew (e.g. Erysiphe cichoracearum UCSC1) (PubMed:11141561,
CC       PubMed:15155802, PubMed:17565954). {ECO:0000269|PubMed:11141561,
CC       ECO:0000269|PubMed:15155802, ECO:0000269|PubMed:17565954}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expressed in leaves after powdery mildew infection (e.g.
CC       Erysiphe cichoracearum UCSC1) (PubMed:15155802). Induced in seedlings
CC       by the beneficial symbiotic fungus Trichoderma atroviride
CC       (PubMed:22942755). {ECO:0000269|PubMed:15155802,
CC       ECO:0000269|PubMed:22942755}.
CC   -!- MISCELLANEOUS: Ecotypes susceptible to Erysiphe cichoracearum, such as
CC       cv. Columbia, are lacking RPW8.1 and RPW8.2 but contain in place HR4.
CC       {ECO:0000305|PubMed:11141561, ECO:0000305|PubMed:15155802}.
CC   -!- SIMILARITY: Belongs to the plant RPW8 protein family. {ECO:0000305}.
CC   -!- CAUTION: Not present in cv. Columbia. The sequence shown is from strain
CC       cv. Ms-0. {ECO:0000305|PubMed:11141561}.
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DR   EMBL; AF273059; AAK09266.1; -; Genomic_DNA.
DR   EMBL; FJ267636; ACJ05898.1; -; Genomic_DNA.
DR   EMBL; FJ267637; ACJ05899.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9C5Z7; -.
DR   SMR; Q9C5Z7; -.
DR   ExpressionAtlas; Q9C5Z7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IDA:UniProtKB.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   GO; GO:0009620; P:response to fungus; IEP:UniProtKB.
DR   GO; GO:0009610; P:response to symbiotic fungus; IEP:UniProtKB.
DR   InterPro; IPR008808; Powdery_mildew-R_dom.
DR   InterPro; IPR039203; RPW8-like.
DR   PANTHER; PTHR36766; PTHR36766; 1.
DR   Pfam; PF05659; RPW8; 1.
DR   PROSITE; PS51153; RPW8; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Hypersensitive response; Membrane; Plant defense;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..148
FT                   /note="Protein RESISTANCE TO POWDERY MILDEW 8.1"
FT                   /id="PRO_0000431675"
FT   TRANSMEM        7..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..148
FT                   /note="RPW8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00495"
FT   COILED          120..140
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   148 AA;  17000 MW;  25179D54C52188C7 CRC64;
     MPIGELAIGA VLGVGAQAIY DRFRKARDIS FVHRLCATIL SIEPFLVQID KRSKVEGSPL
     REVNERLTCF LELAYVFVEA YPKLRRRQVL RKYRYIKAIE TIELALRSII VVDFQVDQWD
     DIKEIKAKIS EMDTKLAEVI SACSKIRA