AB52G_ORYSJ
ID AB52G_ORYSJ Reviewed; 1388 AA.
AC B9G300; Q0J2J4; Q6ESD0;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 2.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=ABC transporter G family member 52 {ECO:0000305};
DE Short=OsABCG52 {ECO:0000305};
DE AltName: Full=Pleiotropic drug resistance protein 18 {ECO:0000303|PubMed:16506311};
DE Short=OsPDR18 {ECO:0000303|PubMed:16506311};
GN Name=ABCG52 {ECO:0000305}; Synonyms=PDR18 {ECO:0000303|PubMed:16506311};
GN OrderedLocusNames=Os09g0333600/Os09g0333500 {ECO:0000312|EMBL:BAF24821.1,
GN ECO:0000312|EMBL:BAF24822.1}, LOC_Os09g16458/LOC_Os09g16449;
GN ORFNames=OsJ_28934 {ECO:0000312|EMBL:EEE69497.1},
GN P0466E03.13 {ECO:0000312|EMBL:BAD28440.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B9G300-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B9G300-2; Sequence=VSP_057781, VSP_057782;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD28440.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF24821.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes Os09g0333500 and Os09g0333600.; Evidence={ECO:0000305};
CC Sequence=BAF24822.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes Os09g0333500 and Os09g0333600.; Evidence={ECO:0000305};
CC Sequence=EEE69497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EEE69497.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AP005128; BAD28440.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008215; BAF24821.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008215; BAF24822.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014965; BAT07540.1; -; Genomic_DNA.
DR EMBL; CM000146; EEE69497.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK072827; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK108694; BAG98494.1; -; mRNA.
DR AlphaFoldDB; B9G300; -.
DR SMR; B9G300; -.
DR STRING; 4530.OS09T0333600-01; -.
DR PRIDE; B9G300; -.
DR EnsemblPlants; Os09t0333600-01; Os09t0333600-01; Os09g0333600. [B9G300-2]
DR Gramene; Os09t0333600-01; Os09t0333600-01; Os09g0333600. [B9G300-2]
DR eggNOG; KOG0065; Eukaryota.
DR OMA; YNGHSME; -.
DR Proteomes; UP000000763; Chromosome 9.
DR Proteomes; UP000007752; Chromosome 9.
DR Proteomes; UP000059680; Chromosome 9.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1388
FT /note="ABC transporter G family member 52"
FT /id="PRO_0000433461"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 621..641
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 646..666
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 675..695
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 732..752
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1136..1156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1167..1183
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 1223..1243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1250..1270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1280..1300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1305..1325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1357..1377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 135..406
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 484..697
FT /note="ABC transmembrane type-2 1"
FT /evidence="ECO:0000305"
FT DOMAIN 791..1043
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1116..1330
FT /note="ABC transmembrane type-2 2"
FT /evidence="ECO:0000305"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 168..175
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 836..843
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT VAR_SEQ 418..422
FT /note="TSRKD -> SFTMV (in isoform 2)"
FT /id="VSP_057781"
FT VAR_SEQ 423..1388
FT /note="Missing (in isoform 2)"
FT /id="VSP_057782"
FT CONFLICT 886
FT /note="I -> V (in Ref. 5; AK072827)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1388 AA; 157291 MW; 146FD254112BDD32 CRC64;
MDDAGEICSF SRSSSSARED DEEDQRWAAL EKLPTYDRAR TALLAMPPDG ELREVNVQRL
AAVERRALLQ RVAGVADDHA RFLAKFKERV DRVGIKLPTV EVRYENLNIE AESYVGRRGL
PTILNTYTII MEGLTNALCI TKKITHKIPI LHNVSGIIKP HRMTLLLGPP GSGKTSLLLA
LAGTSTLKVS GTITYNGHSM EEFVPQRSAA YVSQHDVHMA ELTVRETVNF AAKCQGVGHH
YDLLMELLRR EKEQNIKPDP EIDIYLKAAT TGEQKAEVVT NHILKILGLD ICADTIVGNN
MLRGISGGQK KRLTTAEMIV TPGRALFMDE ISTGLDSSTT FQIVNTIRQT IRILGGTAVI
ALLQPAPETY ELFDDIILLS DGQVVYNGPR DHVLEFFKSV GFKCPERKCV ADFLQEVTSR
KDQKQYWIGS DDTYQYVPVT MIAEAFQSFH VGQAIRSELA IPFEKSKNHP AALATSKYGV
SMKELLKANI YREILLMKRN SFLYIFKAIQ LKLVAINAMT VFIRTNMYRD SIENGRSYMG
ALFYGMMMIV YSALAEMGPA IAKLPVLFKQ RDLLYYPSWT YSLPSWIIKI PISFLNTTVW
VFLTYYVIGF DPNVLRFFRQ FLVLFVLCEV IYALFRFIVA LTRHPVIASN MGPFCILIFM
LSCGFILTRD DVKKWWIWLY WISPLMYALN ALAVNEFLGQ IWNKSILGYK GPLGRLVLGS
SSFLPETKWY WISIGALLGY VLLFNVLYTI CLTFLTHAKE IINDEANSYH ATRHSSAGNK
GMVLPFVPLS ITFEDIRYSV DTPEAFKAKG MTEGRLELLK DISGSFRQGV LTALMGVSGA
GKTTLLDVLA GRKTSGYVQG SITISGYPKK QETFARISGY CEQNDIHSPN VTVYESLMFS
AWLRLPVEID SATRKMFVYE VMELVEILSL KDALVGLPGV SGLSSERRKR LTIAVELVAN
PSIIFMDEPT SGLDARAAAI VMRAIRNTVD TGRTVVCTIH QPSIEIFESF DELFLMKQGG
EEIYVGPIGR QSCELIKYFE AIQGVSKIKD GYNPSTWMLE VTSTTQEQRT CVDFSQIYKN
SELYRRNKNL IKELSAPPEG SSDLSFPTQY SQLFLTQWLA CLWKQHLSYW RNPPYIVVRY
LFTIVVALLF GTMFWGIGKK RQNQQTLFSI MGAMYSACMA MGVQNSSSVQ PAIFVERTIF
YRERASHMYS ALSYALGQVA IEFPYIFLQT IIYCVLVYAM VGYEWTCAKF LWYLFFMFFT
LSYFTFYGMM MAGLTPNNAM SAVVSTAFYN IWNLFSGFLI PRIRIPVWWR WYYWMCPVAW
TLNGLLTSQF GDVNDKFNNG VSVSDFIESY FGYKQDLLWV AAVAVVSFAI LFAFLFGLSL
RLFNFQKR
