ID   AUREO_STAAU             Reviewed;          51 AA.
AC   Q8GPI4;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Bacteriocin aureocin A53;
GN   Name=aucA;
OS   Staphylococcus aureus.
OG   Plasmid pRJ9.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-12; 17-23; 28-44
RP   AND 48-51, FORMYLATION AT MET-1, AND MASS SPECTROMETRY.
RC   STRAIN=A53;
RX   PubMed=12054867; DOI=10.1016/s0022-2836(02)00368-6;
RA   Netz D.J., Pohl R., Beck-Sickinger A.G., Selmer T., Pierik A.J.,
RA   De Freire Bastos M.C., Sahl H.-G.;
RT   "Biochemical characterisation and genetic analysis of aureocin A53, a new,
RT   atypical bacteriocin from Staphylococcus aureus.";
RL   J. Mol. Biol. 319:745-756(2002).
CC   -!- FUNCTION: Antibacterial peptide active against a broad range of lactic
CC       acid bacteria, L.monocytogenes and many epidemiologically unrelated
CC       strains of S.aureus involved in bovine mastitis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=6012.5; Mass_error=0.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:12054867};
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DR   EMBL; AF447813; AAN71834.1; -; Genomic_DNA.
DR   RefSeq; WP_032072954.1; NC_025194.1.
DR   RefSeq; YP_009072012.1; NC_025194.1.
DR   PDB; 2N8O; NMR; -; A=1-51.
DR   PDBsum; 2N8O; -.
DR   AlphaFoldDB; Q8GPI4; -.
DR   BMRB; Q8GPI4; -.
DR   SMR; Q8GPI4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR020968; Bacteriocin_II_aureocin-like.
DR   Pfam; PF11758; Bacteriocin_IIi; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Bacteriocin;
KW   Direct protein sequencing; Formylation; Plasmid; Secreted.
FT   CHAIN           1..51
FT                   /note="Bacteriocin aureocin A53"
FT                   /id="PRO_0000356957"
FT   MOD_RES         1
FT                   /note="N-formylmethionine"
FT                   /evidence="ECO:0000269|PubMed:12054867"
FT   HELIX           4..10
FT                   /evidence="ECO:0007829|PDB:2N8O"
FT   HELIX           11..13
FT                   /evidence="ECO:0007829|PDB:2N8O"
FT   HELIX           17..23
FT                   /evidence="ECO:0007829|PDB:2N8O"
FT   HELIX           25..34
FT                   /evidence="ECO:0007829|PDB:2N8O"
FT   STRAND          35..37
FT                   /evidence="ECO:0007829|PDB:2N8O"
FT   HELIX           38..49
FT                   /evidence="ECO:0007829|PDB:2N8O"
SQ   SEQUENCE   51 AA;  5984 MW;  415A2BBC261319F9 CRC64;
     MSWLNFLKYI AKYGKKAVSA AWKYKGKVLE WLNVGPTLEW VWQKLKKIAG L