AB5A_ARATH
ID AB5A_ARATH Reviewed; 936 AA.
AC Q9STT7; F4JCP4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=ABC transporter A family member 5;
DE Short=ABC transporter ABCA.5;
DE Short=AtABCA5;
DE AltName: Full=Putative ABC2 homolog 4;
GN Name=ABCA5; Synonyms=ATH4; OrderedLocusNames=At3g47760; ORFNames=T23J7.90;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB41859.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049746; CAB41859.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; ANM63942.1; -; Genomic_DNA.
DR PIR; T07715; T07715.
DR RefSeq; NP_001326002.1; NM_001339334.1.
DR AlphaFoldDB; Q9STT7; -.
DR SMR; Q9STT7; -.
DR STRING; 3702.AT3G47760.1; -.
DR PRIDE; Q9STT7; -.
DR EnsemblPlants; AT3G47760.3; AT3G47760.3; AT3G47760.
DR GeneID; 823930; -.
DR Gramene; AT3G47760.3; AT3G47760.3; AT3G47760.
DR KEGG; ath:AT3G47760; -.
DR Araport; AT3G47760; -.
DR eggNOG; KOG0059; Eukaryota.
DR InParanoid; Q9STT7; -.
DR OMA; NTSHAIV; -.
DR OrthoDB; 131191at2759; -.
DR PhylomeDB; Q9STT7; -.
DR PRO; PR:Q9STT7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9STT7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..936
FT /note="ABC transporter A family member 5"
FT /id="PRO_0000240326"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 614..851
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 652..659
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 936 AA; 105584 MW; EF032876CB761AFD CRC64;
MGNHVPAGFF TQANSLFRKN LTYQKRNIWS NVRLIVIPFY LCVLLVGIQV LFDTQVNNSA
DNRCGCRCID KNGDGKCGQK SCGLQYSSQN QAFFCAFPNP PPLLPLLHIP RPETRSSDRD
RDSCRQTGSC PVTILLTGNN HSLGTTISRN LLSTSFAMNS SDLFLRNLAY NVLGTTSKAD
YTNYLDPGIL SDLPIFNVQP RCTPDTTTFS FPFRQSPLEF HKEVRCVEGL NLWRNNSIEI
SNEIFKGYRQ GNLEEIINEV AAAYDLMDTD INNFNVTIWY NSTYKGDLRD RRVKYVRVPR
SVNLVSNAYL EFLQGSGTKM LFDFVKEMPK QETRLRLEMA SLIGPIFFTW VILLLFPVML
TSLVYEKQQH LRIIMKMHGL GDGPYWMITY AYFLAISIVY IICLMIFGSA IGLKFFRFND
YSIQFIFYFL CINLQISIAF LVSSAFSKIE TASVAAYLYV FGSGLLGAFL FQFLLEGLSF
PRSWIYIMEL YPGFSLYRGL YEFSQYAFKR NLNGSGGMKW KDFNDSAMEE IFYIIIVEWF
VALIAAYYTD KISSSGIDPF FFLKNQNPFK KSPSPYGLQR QVSAIAIEME KLDVAHERVK
VEQLMLETST GHAIVCDNLK KVYPCRDGNP QKMAVRGLSL AVPSGECFGM LGPNGAGKTS
FINMMTGLMK PTSGAAFVHG LDICKDMDIV YTSIGVCPQH DLLWETLTGR EHLLFYGRLK
NLKGSDLDQA VEESLKSVNL FRGGVADKPA GKYSGGMKRR LSVAISLIGS PKVVYMDEPS
TGLDPASRRS LWTAIKRAKN HTAIILTTHS MEEAEFLCDR LGIFVDGRLQ CVGNPKELKA
RYGGSYVLTM TTPSEHEKDV EMLVQDVSPN AKKIYHIAGT QKFEIPKEEV RISEVFQAVE
KAKDNFRVFA WGLADTTLED VFIKVARTAQ ASNVFS
