ID   AURF_CALAK              Reviewed;         558 AA.
AC   A0A0M4LAF6;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   09-DEC-2015, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Aurovertin biosynthesis cluster transcription factor aurF {ECO:0000303|PubMed:26340065};
DE   AltName: Full=Aurovertin biosynthesis cluster protein F {ECO:0000303|PubMed:26340065};
GN   Name=aurF {ECO:0000303|PubMed:26340065};
OS   Calcarisporium arbuscula (Dendryphion arbuscula).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreales incertae sedis; Calcarisporium.
OX   NCBI_TaxID=240499;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=26340065; DOI=10.1021/jacs.5b07816;
RA   Mao X.M., Zhan Z.J., Grayson M.N., Tang M.C., Xu W., Li Y.Q., Yin W.B.,
RA   Lin H.C., Chooi Y.H., Houk K.N., Tang Y.;
RT   "Efficient biosynthesis of fungal polyketides containing the dioxabicyclo-
RT   octane ring system.";
RL   J. Am. Chem. Soc. 137:11904-11907(2015).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of aurovertins, fungal
CC       polyketides that exhibit potent inhibition of adenosine triphosphate
CC       synthase (PubMed:26340065). {ECO:0000269|PubMed:26340065}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Blocks the expression of the aurovertin gene
CC       cluster and impairs the production of aurovertins (PubMed:26340065).
CC       {ECO:0000269|PubMed:26340065}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; KT581579; ALD83632.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M4LAF6; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..558
FT                   /note="Aurovertin biosynthesis cluster transcription factor
FT                   aurF"
FT                   /id="PRO_0000443970"
SQ   SEQUENCE   558 AA;  61063 MW;  BD596FC2C9F81938 CRC64;
     MCRFVDAIKS LLDESDITTL VALANRLSPF RVDYRRVVVG DALSVKPILV LEHEQPPCDG
     AWRSAAHINL GLGAAQQQHH PVPTRAVHGA AVGGVQCDGL ASPPVSNNVM SDGTVDGDDD
     DLGYDQDTLY NQGTDYENEG GAVGQDGLPA PDAGLFQECM FSHRSASTPR AGGHGESYCQ
     EVAQSSHAIT CRELLERCIL PNFEINHLEN CESSTSGGIH HCLPDEHSGM TGLARNTPSA
     SPVENSITVE LDGALEIATD VRTGKFNTLR AAKRHRRNTS SLRLSSHDAG CVGDARSSAG
     VVKSPARRST AVSDAALRKV KYAARTCIRA DYFQFLEANL PRWVRDGIWG KEWSPNQTAN
     VDGYENLQKA YWHVCRLDRQ MRDDAIRSRM AMVLLHLEYE NTCLSWKTCA HSGKKPVTKV
     GRGNISSLID NIIENTHPEW RTADPGERSE LRAKFHDRKR YGKRWWMLVK PLGSSILMLC
     SSKFAGMIKN TTVTAAMINE IKLAIQRSET GLMSLLSLAN PIAESLFLDQ GYDGHNAEQV
     LKALRAARLE VAPGEGVA