AURR2_GIBZE
ID AURR2_GIBZE Reviewed; 670 AA.
AC I1RF57;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Aurofusarin cluster transcription factor aurR2 {ECO:0000303|PubMed:16879655};
DE AltName: Full=Aurofusarin biosynthesis cluster protein R2 {ECO:0000303|PubMed:16879655};
DE AltName: Full=Gibberella pigment protein 5 {ECO:0000303|PubMed:16461721};
GN Name=aurR2 {ECO:0000303|PubMed:16879655};
GN Synonyms=GIP5 {ECO:0000303|PubMed:16461721};
GN ORFNames=FG02323, FGRAMPH1_01T05591;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [4]
RP FUNCTION.
RX PubMed=15809006; DOI=10.1016/j.fgb.2005.01.010;
RA Malz S., Grell M.N., Thrane C., Maier F.J., Rosager P., Felk A.,
RA Albertsen K.S., Salomon S., Bohn L., Schaefer W., Giese H.;
RT "Identification of a gene cluster responsible for the biosynthesis of
RT aurofusarin in the Fusarium graminearum species complex.";
RL Fungal Genet. Biol. 42:420-433(2005).
RN [5]
RP FUNCTION.
RX PubMed=16879655; DOI=10.1111/j.1365-2958.2006.05295.x;
RA Frandsen R.J., Nielsen N.J., Maolanon N., Soerensen J.C., Olsson S.,
RA Nielsen J., Giese H.;
RT "The biosynthetic pathway for aurofusarin in Fusarium graminearum reveals a
RT close link between the naphthoquinones and naphthopyrones.";
RL Mol. Microbiol. 61:1069-1080(2006).
RN [6]
RP FUNCTION, AND INDUCTION.
RX PubMed=16461721; DOI=10.1128/aem.72.2.1645-1652.2006;
RA Kim J.E., Jin J., Kim H., Kim J.C., Yun S.H., Lee Y.W.;
RT "GIP2, a putative transcription factor that regulates the aurofusarin
RT biosynthetic gene cluster in Gibberella zeae.";
RL Appl. Environ. Microbiol. 72:1645-1652(2006).
CC -!- FUNCTION: Transcription factor that may participate in the regulation
CC of the expression of the gene cluster that mediates the biosynthesis of
CC aurofusarin, a red mycelium pigment which is acting as a mycotoxin
CC (PubMed:15809006, PubMed:16879655, PubMed:16461721).
CC {ECO:0000269|PubMed:15809006, ECO:0000269|PubMed:16461721,
CC ECO:0000269|PubMed:16879655}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- INDUCTION: Expression is regulated by the aurofusarin biosynthesis
CC cluster-specific transcription facto aurR1/GIP2 (PubMed:16461721).
CC {ECO:0000269|PubMed:16461721}.
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DR EMBL; HG970332; CEF74600.1; -; Genomic_DNA.
DR RefSeq; XP_011318232.1; XM_011319930.1.
DR AlphaFoldDB; I1RF57; -.
DR GeneID; 23549705; -.
DR KEGG; fgr:FGSG_02323; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G05591; -.
DR eggNOG; ENOG502QYWX; Eukaryota.
DR HOGENOM; CLU_004083_5_3_1; -.
DR InParanoid; I1RF57; -.
DR PHI-base; PHI:1972; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..670
FT /note="Aurofusarin cluster transcription factor aurR2"
FT /id="PRO_0000441085"
FT DNA_BIND 12..38
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 57..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 75049 MW; A13B507E92327B64 CRC64;
MTEAKLTRGH SCVPCQHRKI RCNGQTPCAY CIRTGKECVR MRVSPSHSRN ARLNHRRLTA
AQTGSPSGDG QVIVSGDQRR YVEDNKLWKS LGDEMQGKDV SPDPERPPLR TRTDTPSTEV
NLIFSHQRPT SISVKYPSAV HSFQLWQVFI SNVHPLTKIL HGPTVQKDIL ETFSEPTSTP
GPTEALIFAI YLVAVVSLTD AECRSRFGEP RKDLLARYCN ATEVALSKAD FLRSTDLRVL
QAFTLHLLSL RHICDHDILW LLTGLATRMG QRMGLHRESS LKDLPPFEAE LRRRVWWQIV
ILDGRASQLT GASMNPNMQL YGDTQQPINL SDADLVPSAS TIPQPSPITT DMLFCKVRIE
IGVWMIEQKC LLGSESESST TGKAKFFKAI DELERHIEEK YLANMDKELP LNLLTAYLAR
SAVCQLRLSV YHPIHRPERA SDLSAEQIDM LLENSLEVIR YDILSHSTPA LQCYLWHIAN
FFPFETFVLL ISTLSGRPAG QVVDTAWEVI DQVYEHHPSF VSDTSDPLYW ALGNITLKAW
DQRVTSARTR GITVPRELPC IANLVHARAT MARASSQQPS TTDVSGPATP QSLLLAQEAP
VDYLGGLGTT NELASQTDLG MATGEELLGM MKGVDVDWDF WQQLLDGNGH DARARDDQET
FYFSSFINKA
