AB6A_ARATH
ID AB6A_ARATH Reviewed; 926 AA.
AC Q9STT6; F4JCP5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=ABC transporter A family member 6;
DE Short=ABC transporter ABCA.6;
DE Short=AtABCA6;
DE AltName: Full=Putative ABC2 homolog 5;
GN Name=ABCA6; Synonyms=ATH5; OrderedLocusNames=At3g47770; ORFNames=T23J7.100;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEE78327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB41860.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049746; CAB41860.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78327.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; ANM65245.1; -; Genomic_DNA.
DR PIR; T07716; T07716.
DR RefSeq; NP_001327229.1; NM_001339335.1.
DR RefSeq; NP_190361.2; NM_114645.3.
DR AlphaFoldDB; Q9STT6; -.
DR SMR; Q9STT6; -.
DR STRING; 3702.AT3G47770.1; -.
DR PRIDE; Q9STT6; -.
DR EnsemblPlants; AT3G47770.2; AT3G47770.2; AT3G47770.
DR GeneID; 823931; -.
DR Gramene; AT3G47770.2; AT3G47770.2; AT3G47770.
DR KEGG; ath:AT3G47770; -.
DR Araport; AT3G47770; -.
DR eggNOG; KOG0059; Eukaryota.
DR InParanoid; Q9STT6; -.
DR OrthoDB; 130188at2759; -.
DR PhylomeDB; Q9STT6; -.
DR PRO; PR:Q9STT6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9STT6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..926
FT /note="ABC transporter A family member 6"
FT /id="PRO_0000240327"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 525..545
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 610..847
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 648..655
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 926 AA; 104598 MW; CFE609D113A18985 CRC64;
MAKPVAASFL TQANALFKKN LTYQKRNIWS NVRLIVIPLY LCVVLVCIQA VFDSLVNNSV
DNQCGCRCAD DDKNGDGKCE IKSCGLQYSS QNQAVFCAFP NPPPLLPLLH IPPSVNRDSC
QRTGSCPVTI LVTGNNQSLG TTLSENLLST SFTVNSSSDL FLRNLAYNVL STTSETDYTN
YRDPGIYSDL PIFNIQPQCT PATILSLSFR QPPLEFHKEV RCVQGLNLWR NNSLEVNDEI
FKGFRKENHE EIINEVAAAY DLLNTDRNKF NVTIWYYTTY KGDLQDWRVK YVRVPRSVNM
VSNAYLQFLR GPGTKILFDF VKEMPKQETR LRMDMASLIG PIFFTWVILL LFPVILTSLV
YEKQQRLRII MKMHGLGDAP YWMISYAYFL AISTLYIVCL MIFGSAIGLK FFRFNDYTIQ
FMFYFLYINL QISIAFLVSS AFSKAVTASV VAYIYVFGSG LLGAFLFQFL IESLSFPRRW
IFVMELYPGF SLYRGLYEFS QYAFQRNLNG RDGMKWKDFR GSAMDEVFTI IIVEWVVALV
ATYYIDRVSS SSKDTFAFLK NPFKLSPTPQ MLSFQKERSD VSVEMEKLDV IQEKETVKQL
IFERSKNHGI VCDNLKKVYQ GRDGNPPKLA VCGLSLAVPS GECFGMLGPN GAGKTSFINM
MTGLVKPSSG SAFVQGLDIC KDMDKVYISM GVCPQHDLLW ETLTGKEHLL FYGRLKNLKG
HDLNQAVEES LKSVNLFHGG VADIPAGKYS GGMKRRLSVA ISLIGSPKVV YMDEPSTGLD
PASRINLWTV IKRAKKHAAI ILTTHSMEEA EFLCDRLGIF VDGRLQCIGN PKELKGRYGG
SYVLTITTSP EHEKDVETLV QEVSSNARKI YHIAGTQKFE FPKEEVRISE VFQAVENAKR
NFTVFAWGFA DTTLEDVFIK VAKTGL
