ID   AUSY_PENBI              Reviewed;         588 AA.
AC   A0A0F7U0Z9;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2015, sequence version 1.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=MFS-type transporter ausY {ECO:0000303|PubMed:29076725};
DE   AltName: Full=Austinoid biosynthesis clusters protein Y {ECO:0000303|PubMed:29076725};
GN   Name=ausY {ECO:0000303|PubMed:29076725}; ORFNames=PMG11_09851;
OS   Penicillium brasilianum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=104259;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG11;
RX   PubMed=26337871; DOI=10.1128/genomea.00724-15;
RA   Horn F., Linde J., Mattern D.J., Walther G., Guthke R., Brakhage A.A.,
RA   Valiante V.;
RT   "Draft genome sequence of the fungus Penicillium brasilianum MG11.";
RL   Genome Announc. 3:0-0(2015).
RN   [2]
RP   FUNCTION.
RX   PubMed=29076725; DOI=10.1021/acschembio.7b00814;
RA   Mattern D.J., Valiante V., Horn F., Petzke L., Brakhage A.A.;
RT   "Rewiring of the austinoid biosynthetic pathway in filamentous fungi.";
RL   ACS Chem. Biol. 12:2927-2933(2017).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster A that
CC       mediates the biosynthesis of the fungal meroterpenoid
CC       acetoxydehydroaustin. {ECO:0000269|PubMed:29076725}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- MISCELLANEOUS: In A.calidoustus, the austinoid gene cluster lies on a
CC       contiguous DNA region, while clusters from E.nidulans and P.brasilianum
CC       are split in their respective genomes. Genetic rearrangements provoked
CC       variability among the clusters and E.nidulans produces the least number
CC       of austionoid derivatives with the end products austinol and
CC       dehydroaustinol, while P.brasilianum can produce until
CC       acetoxydehydroaustin, and A.calidoustus produces the highest number of
CC       identified derivatives. {ECO:0000305|PubMed:29076725}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; CDHK01000010; CEJ61315.1; -; Genomic_DNA.
DR   SMR; A0A0F7U0Z9; -.
DR   EnsemblFungi; CEJ61315; CEJ61315; PMG11_09851.
DR   OrthoDB; 627633at2759; -.
DR   Proteomes; UP000042958; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..588
FT                   /note="MFS-type transporter ausY"
FT                   /id="PRO_0000453877"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        478..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        554..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   588 AA;  62759 MW;  56B6937E445BFCD2 CRC64;
     MITESREHLA SKPLNSESII RLDTPDDKPS LECESIPSGG HISDVSGGPV STEVKDVNDV
     SEFEKCAMEE QTHDEVPISA SKITVVVAGL VLAVFCMSLD STILATAIPK IVSQFHSQNE
     MGWYVSAYSL TLASFSLAFG KIYTFYPAKI VFLITLSLFE AGSLICGAAP NSLALIIGRA
     IAGIGGTGMY LGSLLLVAEI LPFDKVPIIT ALLAAMYGIA AVVGPLLGGA FADYATWRWC
     FYINLPMGGL TFLFVFFFVK TGNDRKRARE ANNIVSRFLE LDPIGVALLI PTLICLLLAL
     EWGGATYSWH SWRLIVLYVV GGCCALGFVG VQIWRQDTAT LPPRLLKNRN IWGTILFTFC
     LNGSFVVLAY YLPIWFQSIK GVSAIQSGIM NLPLILVMVI CSLLCSTLVT KLGYYTPFLY
     LAPIIASTGA GLLSTMHVNS GSSVWIGFQA LFGIGLGCGL SLSIVAAQTA LPPQDIPTGT
     AIVAFTQTLA AAVFNFVAQN VFQNQVLSGL AQAAPGVSAA KLTKAGPTML REIVPADTLP
     AVLEVYNTAI TRAFYVAVGS AALAIFGAIP LQWLSVKNKK IQAVTAHA