AB6G_ARATH
ID AB6G_ARATH Reviewed; 727 AA.
AC Q9FNB5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=ABC transporter G family member 6;
DE Short=ABC transporter ABCG.6;
DE Short=AtABCG6;
DE AltName: Full=White-brown complex homolog protein 6;
DE Short=AtWBC6;
GN Name=ABCG6; Synonyms=WBC6; OrderedLocusNames=At5g13580; ORFNames=MSH12.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR EMBL; AB006704; BAB08684.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91914.1; -; Genomic_DNA.
DR EMBL; BT003884; AAO41933.1; -; mRNA.
DR EMBL; BT004956; AAO50489.1; -; mRNA.
DR RefSeq; NP_196862.1; NM_121361.3.
DR AlphaFoldDB; Q9FNB5; -.
DR SMR; Q9FNB5; -.
DR BioGRID; 16480; 14.
DR IntAct; Q9FNB5; 13.
DR STRING; 3702.AT5G13580.1; -.
DR TCDB; 3.A.1.204.31; the atp-binding cassette (abc) superfamily.
DR iPTMnet; Q9FNB5; -.
DR PaxDb; Q9FNB5; -.
DR PRIDE; Q9FNB5; -.
DR ProteomicsDB; 244614; -.
DR EnsemblPlants; AT5G13580.1; AT5G13580.1; AT5G13580.
DR GeneID; 831202; -.
DR Gramene; AT5G13580.1; AT5G13580.1; AT5G13580.
DR KEGG; ath:AT5G13580; -.
DR Araport; AT5G13580; -.
DR TAIR; locus:2173184; AT5G13580.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; Q9FNB5; -.
DR OMA; ANIGYAC; -.
DR OrthoDB; 1022017at2759; -.
DR PhylomeDB; Q9FNB5; -.
DR PRO; PR:Q9FNB5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FNB5; baseline and differential.
DR Genevisible; Q9FNB5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1903825; P:organic acid transmembrane transport; IDA:TAIR.
DR GO; GO:0009624; P:response to nematode; HEP:TAIR.
DR GO; GO:0010345; P:suberin biosynthetic process; IGI:TAIR.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..727
FT /note="ABC transporter G family member 6"
FT /id="PRO_0000240678"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 517..537
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 700..720
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 68..333
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 421..631
FT /note="ABC transmembrane type-2"
FT BINDING 126..133
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 727 AA; 80301 MW; 6345CCF5877213A4 CRC64;
MSRVVAADDN MALPFFSPEF GNVSGASSSP TTFAQLLQNV DDSTRRSHHQ HHVDVDLASP
DQSVPFVLSF TDLTYSVKVR RKFTWRRSVS SDPGAPSEGI FSSKTKTLLN GITGEARDGE
ILAVLGASGS GKSTLIDALA NRIAKGSLKG NVTLNGEVLN SKMQKAISAY VMQDDLLFPM
LTVEETLMFA AEFRLPRSLS KSKKSLRVQA LIDQLGLRNA ANTVIGDEGH RGISGGERRR
VSIGIDIIHD PILLFLDEPT SGLDSTSALS VIKVLKRIAQ SGSMVIMTLH QPSYRLLRLL
DRLLFLSRGQ TVFSGSPAML PRFFAEFGHP IPEHENRTEF ALDLIRELEG SAGGTRSLVE
FNKGFRQRKA EPRSQTGLSL KEAISASISK GKLVSGATTT THSSGSSPVS TIPTFANPFW
VELAVLAKRS MTNSRRQPEL FGIRLGAVLV TGFILATMFW QLDNSPKGVQ ERLGCFAFAM
STTFYTCADA LPVFLQERFI FMRETAYNAY RRSSYVLSHS LVALPSLIIL SLAFAAITFW
GVGLDGGLMG FLFYFLVILA SFWAGSSFVT FLSGVVPHVM LGYTIVVAIL AYFLLFSGFF
INRDRIPGYW IWFHYISLVK YPYEAVLLNE FGDPTKCFVR GVQIFDNTPL VAVPQGMKVR
LLATMSKSLG MRITSSTCLT TGYDILQQQG VTDLTKWNCL WVTVAWGFFF RILFYFSLLL
GSKNKRR
