位置:首页 > 蛋白库 > AUXI2_ARATH
AUXI2_ARATH
ID   AUXI2_ARATH             Reviewed;         891 AA.
AC   Q0WQ57; Q9SU09;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Auxilin-related protein 2;
GN   OrderedLocusNames=At4g12770; ORFNames=T20K18.120;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18433157; DOI=10.1021/pr8000173;
RA   de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,
RA   Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C., Lorkovic Z.J.,
RA   Barta A., Lecourieux D., Verhounig A., Jonak C., Hirt H.;
RT   "Site-specific phosphorylation profiling of Arabidopsis proteins by mass
RT   spectrometry and peptide chip analysis.";
RL   J. Proteome Res. 7:2458-2470(2008).
CC   -!- FUNCTION: Promotes probably uncoating of clathrin-coated vesicles.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18433157}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q0WQ57-1; Sequence=Displayed;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB40994.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB78319.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL049640; CAB40994.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161534; CAB78319.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE83177.1; -; Genomic_DNA.
DR   EMBL; AK228848; BAF00742.1; -; mRNA.
DR   PIR; T06635; T06635.
DR   RefSeq; NP_193013.2; NM_117346.4. [Q0WQ57-1]
DR   AlphaFoldDB; Q0WQ57; -.
DR   SMR; Q0WQ57; -.
DR   STRING; 3702.AT4G12770.1; -.
DR   iPTMnet; Q0WQ57; -.
DR   PaxDb; Q0WQ57; -.
DR   PRIDE; Q0WQ57; -.
DR   ProteomicsDB; 240932; -. [Q0WQ57-1]
DR   EnsemblPlants; AT4G12770.1; AT4G12770.1; AT4G12770. [Q0WQ57-1]
DR   GeneID; 826889; -.
DR   Gramene; AT4G12770.1; AT4G12770.1; AT4G12770. [Q0WQ57-1]
DR   KEGG; ath:AT4G12770; -.
DR   Araport; AT4G12770; -.
DR   TAIR; locus:2135763; AT4G12770.
DR   eggNOG; KOG0431; Eukaryota.
DR   InParanoid; Q0WQ57; -.
DR   OMA; ADSMFNS; -.
DR   OrthoDB; 319959at2759; -.
DR   PhylomeDB; Q0WQ57; -.
DR   PRO; PR:Q0WQ57; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q0WQ57; baseline and differential.
DR   Genevisible; Q0WQ57; AT.
DR   GO; GO:0009504; C:cell plate; IDA:TAIR.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IDA:TAIR.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR   GO; GO:0030276; F:clathrin binding; IBA:GO_Central.
DR   GO; GO:0072318; P:clathrin coat disassembly; IBA:GO_Central.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IPI:TAIR.
DR   GO; GO:1900186; P:negative regulation of clathrin-dependent endocytosis; IDA:TAIR.
DR   GO; GO:0045806; P:negative regulation of endocytosis; IDA:TAIR.
DR   GO; GO:0045926; P:negative regulation of growth; IDA:TAIR.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR036869; J_dom_sf.
DR   SUPFAM; SSF46565; SSF46565; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Chaperone; Coiled coil; Cytoplasm;
KW   Reference proteome.
FT   CHAIN           1..891
FT                   /note="Auxilin-related protein 2"
FT                   /id="PRO_0000395460"
FT   DOMAIN          606..627
FT                   /note="R"
FT   DOMAIN          826..891
FT                   /note="J"
FT   REGION          68..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..764
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          454..666
FT                   /evidence="ECO:0000255"
FT   COILED          749..793
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        148..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..187
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..353
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..379
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..448
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..538
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..642
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        654..720
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        746..764
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   891 AA;  98327 MW;  5DE008B8145F4E90 CRC64;
     MDDFTGLLAR DFGLKPQGKS APMASQSNSS AADFNTFASS YSFASAAGKK SDSLPVFDDL
     GRDGDDLLFR DVFSGPPPKY GSSGDSRSPS APAFDYDVMF KEPKSKSASS MPVYDKPVYD
     DEDVFESIPE LKIPSTSSQS ARFENVFSSI SSSPTKHRKQ NSSPFDDLMG NNLGKKESDR
     EEKGSSIFDD LIPGFGRTSS PPAKRTTSET TSQSQKPPYR TAETSSNVKE DPFVVLEEST
     STLREPSTGG FTDPLEEIGK FNSRKTDHSS VHGGVFVDTD PLDSLGKSGP DMNSRGKSHL
     RPPGNISGSQ SPVESSGLYH SKNVSFDDVV EPQNTSTPPP TNSDGSFESS DDVWLTVSEI
     PLFTQPTSAP PPTRPPPPRP TRPIKKKVNE PSIPTSAYHS HVPSSGRASV NSPTASQMDE
     LDDFSIGRNQ TAANGYPDPS SGEDSDVFST AAASAAAMKD AMDKAEAKFR HAKERREKES
     LKASRSREGD HTENYDSRER ELREKQVRLD RERAEREAEM EKTQAREREE REREQKRIER
     ERERLLARQA VERATREARE RAATEAHAKV QRAAVGKVTD ARERAERAAV QRAHAEARER
     AAAGAREKAE KAAAEARERA NAEVREKEAK VRAERAAVER AAAEARGRAA AQAKAKQQQE
     NNNDLDSFFN SVSRPSSVPR QRTNPPDPFQ DSWNKGGSFE SSRPSSRVPS GPTENLRKAS
     SATNIVDDLS SIFGAPASQS GGFQDVDGET EERRRARLER HQRTQERAAK ALAEKNERDL
     QVQREQAEKD RIGGTLDVEI RRWGAGKEGN LRALLSTLQY VLWPECGWQP VSLTDLITGA
     SVKKVYRKAT LCIHPDKVQQ KGANLQQKYI AEKVFDMLKE AWNKFNSEEL F
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024