AV238_PHYSO
ID AV238_PHYSO Reviewed; 134 AA.
AC G1FSB5;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 16.
DE RecName: Full=RxLR effector protein Avh238 {ECO:0000303|PubMed:21653195};
DE AltName: Full=Avirulence homolog protein 238 {ECO:0000303|PubMed:21653195};
DE Flags: Precursor;
GN Name=Avh238 {ECO:0000303|PubMed:21653195};
OS Phytophthora sojae (Soybean stem and root rot agent) (Phytophthora
OS megasperma f. sp. glycines).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=67593;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, FUNCTION, INDUCTION, AND
RP DOMAIN.
RC STRAIN=P7076;
RX PubMed=21653195; DOI=10.1105/tpc.111.086082;
RA Wang Q., Han C., Ferreira A.O., Yu X., Ye W., Tripathy S., Kale S.D.,
RA Gu B., Sheng Y., Sui Y., Wang X., Zhang Z., Cheng B., Dong S., Shan W.,
RA Zheng X., Dou D., Tyler B.M., Wang Y.;
RT "Transcriptional programming and functional interactions within the
RT Phytophthora sojae RXLR effector repertoire.";
RL Plant Cell 23:2064-2086(2011).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF ASN-79.
RX PubMed=28134441; DOI=10.1111/nph.14430;
RA Yang B., Wang Q., Jing M., Guo B., Wu J., Wang H., Wang Y., Lin L.,
RA Wang Y., Ye W., Dong S., Wang Y.;
RT "Distinct regions of the Phytophthora essential effector Avh238 determine
RT its function in cell death activation and plant immunity suppression.";
RL New Phytol. 214:361-375(2017).
CC -!- FUNCTION: Effector that, due to the lack of a histidine residue at
CC position 79, is not able to induce cell death in tomato, tobacco,
CC eggplant, potato, or in A.thaliana. {ECO:0000269|PubMed:21653195,
CC ECO:0000269|PubMed:28134441}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28134441}. Host
CC cytoplasm {ECO:0000269|PubMed:28134441}. Host nucleus
CC {ECO:0000269|PubMed:28134441}.
CC -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC phosphate. {ECO:0000305|PubMed:21653195}.
CC -!- MISCELLANEOUS: Avh238 is highly polymorphic among P.sojae isolates.
CC {ECO:0000269|PubMed:28134441}.
CC -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR EMBL; JN254190; AEK81003.1; -; Genomic_DNA.
DR AlphaFoldDB; G1FSB5; -.
DR SMR; G1FSB5; -.
DR VEuPathDB; FungiDB:PHYSODRAFT_285342; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Host cytoplasm; Host nucleus; Secreted; Signal; Virulence.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..134
FT /note="RxLR effector protein Avh238"
FT /evidence="ECO:0000255"
FT /id="PRO_5003412241"
FT REGION 50..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 44..68
FT /note="RxLR-dEER"
FT /evidence="ECO:0000305|PubMed:21653195"
FT MUTAGEN 79
FT /note="N->H: Restores the ability to induce cell death in
FT host."
FT /evidence="ECO:0000269|PubMed:28134441"
SQ SEQUENCE 134 AA; 14100 MW; 5FE4D7778EE373B5 CRC64;
MRGVFFVAVA VAIFARSSAE AKLLSEAAPG LAADAVISGE SRERFLRVAD SEDDDLAAPA
DDGKTEERAP KFKSLSEINK KLDEEVMVHV SKILGNMGAI HADNIAKARA ALEAAHKSGD
ITDKQLAAGL AKLV
