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AB6I_ARATH
ID   AB6I_ARATH              Reviewed;         338 AA.
AC   Q9CAF5; Q8LF74; Q9LPN3; Q9SG74;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=ABC transporter I family member 6, chloroplastic;
DE            Short=ABC transporter ABCI.6;
DE            Short=AtABCI6;
DE   AltName: Full=ABC transporter ATPase;
DE   AltName: Full=Non-intrinsic ABC protein 7;
DE            Short=AtNAP7;
DE   AltName: Full=Plastid SufC-like protein;
DE   Flags: Precursor;
GN   Name=ABCI6; Synonyms=NAP7; OrderedLocusNames=At3g10670;
GN   ORFNames=F13M14.4, F18K10.29, T7M13.25;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION, FUNCTION, INTERACTION WITH NAP6, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15184673; DOI=10.1073/pnas.0400799101;
RA   Xu X.M., Moeller S.G.;
RT   "AtNAP7 is a plastidic SufC-like ATP-binding cassette/ATPase essential for
RT   Arabidopsis embryogenesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9143-9148(2004).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA   Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT   "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL   J. Biol. Chem. 276:30231-30244(2001).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=17272265; DOI=10.1074/mcp.m600408-mcp200;
RA   Maor R., Jones A., Nuehse T.S., Studholme D.J., Peck S.C., Shirasu K.;
RT   "Multidimensional protein identification technology (MudPIT) analysis of
RT   ubiquitinated proteins in plants.";
RL   Mol. Cell. Proteomics 6:601-610(2007).
RN   [8]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA   Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
CC   -!- FUNCTION: Essential protein. Required during embryo development,
CC       especially at early stages. Involved in chloroplast differentiation.
CC       {ECO:0000269|PubMed:15184673}.
CC   -!- SUBUNIT: Interacts with NAP6. {ECO:0000269|PubMed:15184673}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC       {ECO:0000269|PubMed:15184673}.
CC   -!- TISSUE SPECIFICITY: Present in all organs, with higher levels in aerial
CC       parts. {ECO:0000269|PubMed:15184673}.
CC   -!- DEVELOPMENTAL STAGE: During seed development, first expressed in
CC       developing endosperm, embryo and suspensor and later restricted to the
CC       embryo. In seedlings, confined to apical meristems and vascular
CC       tissues. In flowers, mostly present in floral meristem, in filaments of
CC       the stamen and in the style. {ECO:0000269|PubMed:15184673}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCI family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF19582.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAF76373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC011560; AAG51398.1; -; Genomic_DNA.
DR   EMBL; AC011708; AAF19582.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC013428; AAF76373.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE74941.1; -; Genomic_DNA.
DR   EMBL; AY035125; AAK59630.1; -; mRNA.
DR   EMBL; AY113917; AAM44965.1; -; mRNA.
DR   EMBL; AY085010; AAM61568.1; -; mRNA.
DR   EMBL; BK005580; DAA05587.1; -; mRNA.
DR   RefSeq; NP_187678.1; NM_111903.3.
DR   AlphaFoldDB; Q9CAF5; -.
DR   SMR; Q9CAF5; -.
DR   BioGRID; 5570; 1.
DR   IntAct; Q9CAF5; 2.
DR   STRING; 3702.AT3G10670.1; -.
DR   PaxDb; Q9CAF5; -.
DR   PRIDE; Q9CAF5; -.
DR   ProteomicsDB; 244599; -.
DR   EnsemblPlants; AT3G10670.1; AT3G10670.1; AT3G10670.
DR   GeneID; 820236; -.
DR   Gramene; AT3G10670.1; AT3G10670.1; AT3G10670.
DR   KEGG; ath:AT3G10670; -.
DR   Araport; AT3G10670; -.
DR   TAIR; locus:2075880; AT3G10670.
DR   eggNOG; ENOG502QS88; Eukaryota.
DR   HOGENOM; CLU_000604_48_0_1; -.
DR   InParanoid; Q9CAF5; -.
DR   OMA; MAMLEPK; -.
DR   OrthoDB; 957396at2759; -.
DR   PhylomeDB; Q9CAF5; -.
DR   PRO; PR:Q9CAF5; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9CAF5; baseline and differential.
DR   Genevisible; Q9CAF5; AT.
DR   GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR   GO; GO:0009570; C:chloroplast stroma; HDA:TAIR.
DR   GO; GO:0005829; C:cytosol; HDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IDA:TAIR.
DR   GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR   GO; GO:0010027; P:thylakoid membrane organization; IMP:TAIR.
DR   CDD; cd03217; ABC_FeS_Assembly; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR010230; FeS-cluster_ATPase_SufC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43204; PTHR43204; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01978; sufC; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Chloroplast; Nucleotide-binding; Plastid; Reference proteome;
KW   Transit peptide; Transport.
FT   TRANSIT         1..66
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           67..338
FT                   /note="ABC transporter I family member 6, chloroplastic"
FT                   /id="PRO_0000250659"
FT   DOMAIN          92..338
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         126..133
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CONFLICT        23
FT                   /note="S -> F (in Ref. 4; AAM61568)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   338 AA;  36931 MW;  80B74143D1D1938E CRC64;
     MAGVNLQLRH AYSIAQFVPT VSSPPPLPTQ RVRLGTSPSR VLLCNLRANS AAAPILRTTR
     RSVIVSASSV SSAVDSDSLV EDRDDVGRIP LLEVRDLRAV IAESRQEILK GVNLVVYEGE
     VHAVMGKNGS GKSTFSKVLV GHPDYEVTGG SIVFKGQNLL DMEPEDRSLA GLFMSFQSPV
     EIPGVSNMDF LNMAFNARKR KLGQPELDPI QFYSHLVSKL EVVNMKTDFL NRNVNEGFSG
     GERKRNEILQ LAVLGAELAI LDEIDSGLDV DALQDVAKAV NGLLTPKNSV LMITHYQRLL
     DYIKPTLIHI MENGRIIKTG DNSLAKLLEK EGYKAISG
 
 
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