ID   AV2_CLVN                Reviewed;         113 AA.
AC   P14967;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Uncharacterized 13.1 kDa protein;
OS   African cassava mosaic virus (isolate Nigerian) (ACMV) (Cassava latent
OS   virus (isolate Nigerian)).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=222073;
OH   NCBI_TaxID=197394; Hewittia sublobata.
OH   NCBI_TaxID=3996; Jatropha multifida (Coralbush).
OH   NCBI_TaxID=194268; Laportea.
OH   NCBI_TaxID=3983; Manihot esculenta (Cassava) (Jatropha manihot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2308831; DOI=10.1093/nar/18.1.197;
RA   Morris B., Coates L., Lowe S., Richardson K., Eddy P.;
RT   "Nucleotide sequence of the infectious cloned DNA components of African
RT   cassava mosaic virus (Nigerian strain).";
RL   Nucleic Acids Res. 18:197-198(1990).
CC   -!- FUNCTION: Through its interaction with host SGS3, acts as a suppressor
CC       of RNA-mediated gene silencing, also known as post-transcriptional gene
CC       silencing (PTGS), a mechanism of plant viral defense that limits the
CC       accumulation of viral RNAs. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host SGS3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000250}. Note=Accumulates in inclusion bodies in the cell
CC       periphery. May interact with the ER network from the perinuclear region
CC       out to the cell periphery (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae protein AV2/V2 family.
CC       {ECO:0000305}.
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DR   EMBL; X17095; CAA34949.1; -; Genomic_DNA.
DR   PIR; S07590; S07590.
DR   Proteomes; UP000008453; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR   GO; GO:0060967; P:negative regulation of gene silencing by RNA; IEA:InterPro.
DR   InterPro; IPR002511; Gemini_V2.
DR   InterPro; IPR005159; WCCH.
DR   Pfam; PF01524; Gemini_V2; 1.
DR   Pfam; PF03716; WCCH; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Suppressor of RNA silencing.
FT   CHAIN           1..113
FT                   /note="Uncharacterized 13.1 kDa protein"
FT                   /id="PRO_0000222276"
FT   REGION          94..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   113 AA;  13131 MW;  1BC5A30FCDB9BCDB CRC64;
     MWDPLVNEFP DSVHGLRCML AIKYLQALED TYEPSTLGHD LVRDLISVIR ARNYVEATRR
     YHHFHSRLEG SSKAELRQPI QEPCYCPHCP RHKSKTGLDE QAHVQKAHDV QDV