ID   AV2_ICMV                Reviewed;         112 AA.
AC   Q08593;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Protein AV2;
GN   ORFNames=AV2;
OS   Indian cassava mosaic virus (ICMV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=31600;
OH   NCBI_TaxID=3983; Manihot esculenta (Cassava) (Jatropha manihot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8245859; DOI=10.1099/0022-1317-74-11-2437;
RA   Hong Y.G., Robinson D.J., Harrison B.D.;
RT   "Nucleotide sequence evidence for the occurrence of three distinct
RT   whitefly-transmitted geminiviruses in cassava.";
RL   J. Gen. Virol. 74:2437-2443(1993).
CC   -!- FUNCTION: Through its interaction with host SGS3, acts as a suppressor
CC       of RNA-mediated gene silencing, also known as post-transcriptional gene
CC       silencing (PTGS), a mechanism of plant viral defense that limits the
CC       accumulation of viral RNAs. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host SGS3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000250}. Note=Accumulates in inclusion bodies in the cell
CC       periphery. May interact with the ER network from the perinuclear region
CC       out to the cell periphery (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae protein AV2/V2 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z24758; CAA80884.1; -; Genomic_DNA.
DR   PIR; S35880; S35880.
DR   RefSeq; NP_047227.1; NC_001932.1.
DR   GeneID; 991055; -.
DR   KEGG; vg:991055; -.
DR   Proteomes; UP000007210; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR   GO; GO:0060967; P:negative regulation of gene silencing by RNA; IEA:InterPro.
DR   InterPro; IPR002511; Gemini_V2.
DR   InterPro; IPR005159; WCCH.
DR   Pfam; PF01524; Gemini_V2; 1.
DR   Pfam; PF03716; WCCH; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Reference proteome;
KW   Suppressor of RNA silencing.
FT   CHAIN           1..112
FT                   /note="Protein AV2"
FT                   /id="PRO_0000222273"
SQ   SEQUENCE   112 AA;  12986 MW;  A4E9BD8636878D88 CRC64;
     MWDPLLNEFP ESVHGFRCML AVKYLQLVEC TYSPDTLGYD LIRDLFSVIR AKNYVEATSR
     YHNFYSRLEG SSPSELRQPI QQPCGCPYCP RHKKTILDKQ THQSEAQVVS DV