AB7A_ARATH
ID AB7A_ARATH Reviewed; 935 AA.
AC Q9STT5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=ABC transporter A family member 7;
DE Short=ABC transporter ABCA.7;
DE Short=AtABCA7;
DE AltName: Full=Probable ABC2 homolog 6;
GN Name=ABCA7; Synonyms=ATH6; OrderedLocusNames=At3g47780; ORFNames=T23J7.110;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB41861.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049746; CAB41861.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78328.1; -; Genomic_DNA.
DR PIR; T07717; T07717.
DR RefSeq; NP_190362.2; NM_114646.4.
DR AlphaFoldDB; Q9STT5; -.
DR SMR; Q9STT5; -.
DR BioGRID; 9252; 18.
DR IntAct; Q9STT5; 17.
DR STRING; 3702.AT3G47780.1; -.
DR PaxDb; Q9STT5; -.
DR PRIDE; Q9STT5; -.
DR ProteomicsDB; 244334; -.
DR EnsemblPlants; AT3G47780.1; AT3G47780.1; AT3G47780.
DR GeneID; 823932; -.
DR Gramene; AT3G47780.1; AT3G47780.1; AT3G47780.
DR KEGG; ath:AT3G47780; -.
DR Araport; AT3G47780; -.
DR TAIR; locus:2100322; AT3G47780.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_5_1; -.
DR InParanoid; Q9STT5; -.
DR OMA; MISYTYF; -.
DR OrthoDB; 130188at2759; -.
DR PhylomeDB; Q9STT5; -.
DR BioCyc; ARA:AT3G47780-MON; -.
DR PRO; PR:Q9STT5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9STT5; baseline and differential.
DR Genevisible; Q9STT5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..935
FT /note="ABC transporter A family member 7"
FT /id="PRO_0000240328"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 613..850
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 571..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 651..658
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 935 AA; 105048 MW; 62B5FA60608FD7A3 CRC64;
MADPGPASFS TRANALLRKN LTYQKRNLWS NIRLIMIPFY LCILLVIIQI LFDTQVNNSA
DNRCGCECIE RNRAGKCQRE LCGLEHSKPD QAFFCSIPRP PLWPPLLQIP RPESRDVRGL
RDDSCRRTGS CPVTILFTGN NRSLGTTVSE NLFTSSVSAN ASEILRTLAN NVLGTTVEAD
FTNYLDPGIA SNLSIYNIQP RCILNATFPF SFEQPPLKFE KELRCVQGSN LWTNTSKEVN
DKIFKGYKKG NPEGKINEIA AAYDLLNTDR NNFNVHIWYN STYKDDAGNR LIKLIRVPRS
VNLVSNAYLQ FLQGPGTRML FEYVKEMPKP ETSLRLDIAS LIGPLFFTWV ILLLFPVILS
SLVYEKQQHL RIIMKMHGLG DGPYWMISYA YFLTISVLYV ICLMIFGSAI GLKFFRLNSY
SIQFVFYFLY LNLQIALAFL VSSVFSKVKT STVASYIYVF GSGLLGLFLL NFLIEDSSFP
RGWIIVMELY PGFSLYRGLY ELAQFAFRGN LRGEDGMKWK DFGDSAMDDV FYIIVVEWFL
ALIAAYYIDK ISSSGRNPLF FLQNPFKKSP SLRRPSLQRQ GSKVSVDMEK PDVTHESKKV
ERLMLESSTS HAIVCDNLKK VYPGRDGNPP KLAVRGLSLA VPSGECFGML GPNGAGKTSF
INMMTGLLKP TSGTALVQGL DICNDMDRVY TSMGVCPQHD LLWETLTGRE HLLFYGRLKN
LKGADLNQAV EESLKSVNLF HGGVADKPAG KYSGGMKRRL SVAISLIGNP KVVYMDEPST
GLDPASRKNL WTVIKRAKQN TAIILTTHSM EEAEFLCDRL GIFVDGGLQC IGNPKELKGR
YGGSYVFTMT TSSEHEQNVE KLIKDVSPNA KKIYHIAGTQ KFELPKEEVR ISEVFQAVEK
AKSNFTVFAW GLADTTLEDV FIKVVRNGQA FNVFS
