ID   AV2_TYCSV               Reviewed;         115 AA.
AC   P61511; P27270;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Protein V2;
GN   ORFNames=V2;
OS   Tomato yellow leaf curl Sardinia virus (TYLCSV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=123735;
OH   NCBI_TaxID=4072; Capsicum annuum (Capsicum pepper).
OH   NCBI_TaxID=185024; Cynanchum acutum.
OH   NCBI_TaxID=145753; Malva parviflora (Little mallow) (Cheeseweed mallow).
OH   NCBI_TaxID=29728; Sinapis arvensis (Charlock mustard) (Brassica kaber).
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4112; Solanum nigrum (Black nightshade).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1840676; DOI=10.1093/nar/19.24.6763;
RA   Kheyr-Pour A., Bendahmane M., Matzeit V., Accotto G.P., Crespi S.,
RA   Gronenborn B.;
RT   "Tomato yellow leaf curl virus from Sardinia is a whitefly-transmitted
RT   monopartite geminivirus.";
RL   Nucleic Acids Res. 19:6763-6769(1991).
CC   -!- FUNCTION: Through its interaction with host SGS3, acts as a suppressor
CC       of RNA-mediated gene silencing, also known as post-transcriptional gene
CC       silencing (PTGS), a mechanism of plant viral defense that limits the
CC       accumulation of viral RNAs. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host SGS3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000250}. Note=Accumulates in inclusion bodies in the cell
CC       periphery. May interact with the ER network from the perinuclear region
CC       out to the cell periphery (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae protein AV2/V2 family.
CC       {ECO:0000305}.
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DR   EMBL; X61153; CAA43462.1; -; Genomic_DNA.
DR   PIR; S22588; S22588.
DR   RefSeq; NP_620737.1; NC_003828.1.
DR   GeneID; 944420; -.
DR   KEGG; vg:944420; -.
DR   Proteomes; UP000002323; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR   GO; GO:0060967; P:negative regulation of gene silencing by RNA; IEA:InterPro.
DR   InterPro; IPR002511; Gemini_V2.
DR   InterPro; IPR005159; WCCH.
DR   Pfam; PF01524; Gemini_V2; 1.
DR   Pfam; PF03716; WCCH; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Reference proteome;
KW   Suppressor of RNA silencing.
FT   CHAIN           1..115
FT                   /note="Protein V2"
FT                   /id="PRO_0000222279"
SQ   SEQUENCE   115 AA;  13251 MW;  D1AF66654C12A208 CRC64;
     MWDPLLNEFP DSVHGLRCML AIKYLQLVEE TYEPNTLGHD LIRDLISVIR ARDYAEANRR
     YTNFNARLEG SSKTELRQPV YQPCCCPHCP RHQASIMDLQ AHVSKAADVQ NVQKP