ID   AV2_TYLCC               Reviewed;         115 AA.
AC   Q9DXE9;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   12-AUG-2020, entry version 46.
DE   RecName: Full=Protein V2;
GN   ORFNames=V2;
OS   Tomato yellow leaf curl China virus (TYLCCNV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Begomovirus.
OX   NCBI_TaxID=185793;
OH   NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
OH   NCBI_TaxID=185191; Sigesbeckia orientalis.
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate CHI;
RX   PubMed=11682126; DOI=10.1016/s0168-1702(01)00363-x;
RA   Yin Q., Yang H., Gong Q., Wang H., Liu Y., Hong Y., Tien P.;
RT   "Tomato yellow leaf curl China virus: monopartite genome organization and
RT   agroinfection of plants.";
RL   Virus Res. 81:69-76(2001).
CC   -!- FUNCTION: Through its interaction with host SGS3, acts as a suppressor
CC       of RNA-mediated gene silencing, also known as post-transcriptional gene
CC       silencing (PTGS), a mechanism of plant viral defense that limits the
CC       accumulation of viral RNAs. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host SGS3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000250}. Note=Accumulates in inclusion bodies in the cell
CC       periphery. May interact with the ER network from the perinuclear region
CC       out to the cell periphery (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae protein AV2/V2 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF311734; AAG27471.1; -; Genomic_DNA.
DR   RefSeq; NP_660164.1; NC_004044.1.
DR   GeneID; 949225; -.
DR   KEGG; vg:949225; -.
DR   Proteomes; UP000008267; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR   GO; GO:0060967; P:negative regulation of gene silencing by RNA; IEA:InterPro.
DR   InterPro; IPR002511; Gemini_V2.
DR   InterPro; IPR005159; WCCH.
DR   Pfam; PF01524; Gemini_V2; 1.
DR   Pfam; PF03716; WCCH; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Reference proteome;
KW   Suppressor of RNA silencing.
FT   CHAIN           1..115
FT                   /note="Protein V2"
FT                   /id="PRO_0000312155"
SQ   SEQUENCE   115 AA;  13278 MW;  8940F0CDFDEE48C5 CRC64;
     MWDPLLNEFP ETVHGFRCML AIKYLQLVEN TYSPDTLGYD LIRDLISVIR ARDYGETSRR
     YCHFHSRLEG ASPAELRQPL YGSCCCPHCP RHQKTNVVKQ AHVPEAHDVP DVQKP