ID   AVEF_AVESA              Reviewed;          43 AA.
AC   Q09097; Q9S8W7;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Avenin-F;
DE   AltName: Full=Celiac immunoreactive protein 2;
DE            Short=CIP-2;
DE   AltName: Full=Gamma-3-avenin;
DE   AltName: Full=Prolamin;
DE   Flags: Fragment;
OS   Avena sativa (Oat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Poodae; Poeae; Aveninae; Avena.
OX   NCBI_TaxID=4498;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   STRAIN=cv. Rhea {ECO:0000269|PubMed:3120802};
RC   TISSUE=Seed {ECO:0000269|PubMed:3120802};
RX   PubMed=3120802; DOI=10.1016/0300-9084(87)90189-1;
RA   Pernollet J.-C., Huet J.-C., Galle A.-M., Sallantin M.;
RT   "N-terminal sequences of oat avenins compared to other cereal prolamins.";
RL   Biochimie 69:683-689(1987).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 1-29.
RC   TISSUE=Endosperm {ECO:0000269|PubMed:1526282};
RX   PubMed=1526282; DOI=10.1016/0014-5793(92)81141-8;
RA   Rocher A., Colilla F., Ortiz M.L., Mendez E.;
RT   "Identification of the three major coeliac immunoreactive proteins and one
RT   alpha-amylase inhibitor from oat endosperm.";
RL   FEBS Lett. 310:37-40(1992).
CC   -!- FUNCTION: Seed storage protein. Serves as a source of nitrogen, carbon,
CC       and sulfur for the young developing seedling (By similarity).
CC       {ECO:0000250|UniProtKB:P80356}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:P80356}.
CC   -!- SUBCELLULAR LOCATION: Vacuole, aleurone grain {ECO:0000250}.
CC       Note=Protein bodies inside vacuoles. {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Avenins are one of the
CC       causes of celiac disease, also known as celiac sprue or gluten-
CC       sensitive enteropathy (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the gliadin/glutenin family. {ECO:0000255}.
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DR   PIR; S29207; S29207.
DR   PIR; S29208; S29208.
DR   AlphaFoldDB; Q09097; -.
DR   GO; GO:0033095; C:aleurone grain; IEA:UniProtKB-SubCell.
DR   GO; GO:0005773; C:vacuole; IEA:UniProtKB-KW.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Repeat; Seed storage protein;
KW   Storage protein; Vacuole.
FT   CHAIN           1..>43
FT                   /note="Avenin-F"
FT                   /id="PRO_0000239310"
FT   REPEAT          21..26
FT                   /note="1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          27..34
FT                   /note="2; approximate"
FT   REPEAT          35..40
FT                   /note="3"
FT                   /evidence="ECO:0000255"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          21..40
FT                   /note="3 X 6 aa tandem repeats of P-F-V-Q-Q-Q"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        20
FT                   /note="E -> Q (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         43
FT                   /evidence="ECO:0000303|PubMed:3120802"
SQ   SEQUENCE   43 AA;  5214 MW;  C0D4012F3376FDD1 CRC64;
     TTTVQYDPSE QYQPYPEQQE PFVQQQPPFV QQQQPFVQQQ EPF