AVEN_MOUSE
ID AVEN_MOUSE Reviewed; 342 AA.
AC Q9D9K3; A2AGL4;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Cell death regulator Aven;
GN Name=Aven;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82 AND SER-84, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Liver, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Protects against apoptosis mediated by Apaf-1. {ECO:0000250}.
CC -!- SUBUNIT: Binds Apaf-1, BCL-2 and BAD (Bcl-xl). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}. Note=Associated with intracellular
CC membranes. {ECO:0000250}.
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DR EMBL; AK006808; BAB24752.1; -; mRNA.
DR EMBL; AL691423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL731840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466519; EDL27845.1; -; Genomic_DNA.
DR CCDS; CCDS16557.1; -.
DR RefSeq; NP_083120.2; NM_028844.3.
DR AlphaFoldDB; Q9D9K3; -.
DR BioGRID; 216619; 1.
DR STRING; 10090.ENSMUSP00000003705; -.
DR iPTMnet; Q9D9K3; -.
DR PhosphoSitePlus; Q9D9K3; -.
DR EPD; Q9D9K3; -.
DR jPOST; Q9D9K3; -.
DR MaxQB; Q9D9K3; -.
DR PaxDb; Q9D9K3; -.
DR PRIDE; Q9D9K3; -.
DR ProteomicsDB; 273506; -.
DR Antibodypedia; 9528; 365 antibodies from 32 providers.
DR DNASU; 74268; -.
DR Ensembl; ENSMUST00000003705; ENSMUSP00000003705; ENSMUSG00000003604.
DR GeneID; 74268; -.
DR KEGG; mmu:74268; -.
DR UCSC; uc008lpe.2; mouse.
DR CTD; 57099; -.
DR MGI; MGI:1921518; Aven.
DR VEuPathDB; HostDB:ENSMUSG00000003604; -.
DR eggNOG; ENOG502S0YI; Eukaryota.
DR GeneTree; ENSGT00390000003299; -.
DR HOGENOM; CLU_074829_0_0_1; -.
DR InParanoid; Q9D9K3; -.
DR OMA; WDRYQDI; -.
DR OrthoDB; 1340211at2759; -.
DR PhylomeDB; Q9D9K3; -.
DR TreeFam; TF332067; -.
DR Reactome; R-MMU-111458; Formation of apoptosome.
DR Reactome; R-MMU-9627069; Regulation of the apoptosome activity.
DR BioGRID-ORCS; 74268; 1 hit in 40 CRISPR screens.
DR ChiTaRS; Aven; mouse.
DR PRO; PR:Q9D9K3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D9K3; protein.
DR Bgee; ENSMUSG00000003604; Expressed in seminiferous tubule of testis and 195 other tissues.
DR ExpressionAtlas; Q9D9K3; baseline and differential.
DR Genevisible; Q9D9K3; MM.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR InterPro; IPR026187; Aven.
DR PANTHER; PTHR16524; PTHR16524; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Membrane; Phosphoprotein; Reference proteome.
FT CHAIN 1..342
FT /note="Cell death regulator Aven"
FT /id="PRO_0000064769"
FT REGION 1..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 82
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 84
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 281
FT /note="N -> I (in Ref. 1; BAB24752)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 37195 MW; 2DF7498FA8670155 CRC64;
MQAERGARGG RGRRGGRERP GGDREPVGAA TALARGGCGD GGGRRGRGRG FRRGRGGGGL
RGGRWEPGGR GGGASTRVEE DSDSETYGEE NDEQGNFSRR KIVSNWDRYQ DTEKEVNGES
GESQRGTDFS VLLSSAGDSF SQFRFAEEKE WDGETSCPKQ NSALYVDSES LVRALEQLPL
AVRLNVASEL IQTTIPLELP QVKPRRNDDG KELGMHLRGP ISELRSAAGA CPRSLGRGSL
RQSPLEGLQK APTPTQSVAD HLEEELDMLL HLDAPVQEEG NISPDQTSRD QEPEKDGQVA
QEETGPEKPS VTREKNVEPE QPSTSKNVTE EELEDWLDSM IS
