AVE_DROME
ID AVE_DROME Reviewed; 106 AA.
AC Q8ML92;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein aveugle;
GN Name=ave; ORFNames=CG30476;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND INTERACTION WITH
RP CNK.
RX PubMed=16600911; DOI=10.1101/gad.1390506;
RA Roignant J.-Y., Hamel S., Janody F., Treisman J.E.;
RT "The novel SAM domain protein Aveugle is required for Raf activation in the
RT Drosophila EGF receptor signaling pathway.";
RL Genes Dev. 20:795-806(2006).
CC -!- FUNCTION: Required for normal photoreceptor differentiation between Ras
CC and Raf for EGFR signaling in the eye and for mitogen-activated protein
CC kinase phosphorylation. Probably acts together with Cnk to promote Raf
CC activation, perhaps by recruiting an activating kinase.
CC {ECO:0000269|PubMed:16600911}.
CC -!- SUBUNIT: Interacts with the SAM domain of cnk.
CC {ECO:0000269|PubMed:16600911}.
CC -!- INTERACTION:
CC Q8ML92; Q7KNQ9: cnk; NbExp=5; IntAct=EBI-2563975, EBI-111569;
CC Q8ML92; Q8WXI2: CNKSR2; Xeno; NbExp=5; IntAct=EBI-2563975, EBI-1045119;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16600911}. Membrane
CC {ECO:0000269|PubMed:16600911}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16600911}.
CC -!- DEVELOPMENTAL STAGE: Expressed ubiquitously throughout development.
CC {ECO:0000269|PubMed:16600911}.
CC -!- MISCELLANEOUS: 'Aveugle' means 'blind' in French.
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DR EMBL; AE013599; AAM68548.1; -; Genomic_DNA.
DR EMBL; BT001710; AAN71465.1; -; mRNA.
DR RefSeq; NP_725413.1; NM_166066.3.
DR PDB; 3BS5; X-ray; 2.00 A; A=1-106.
DR PDB; 3BS7; X-ray; 1.90 A; A/B=21-98.
DR PDBsum; 3BS5; -.
DR PDBsum; 3BS7; -.
DR AlphaFoldDB; Q8ML92; -.
DR SMR; Q8ML92; -.
DR BioGRID; 73183; 3.
DR DIP; DIP-29737N; -.
DR IntAct; Q8ML92; 3.
DR STRING; 7227.FBpp0086569; -.
DR PaxDb; Q8ML92; -.
DR DNASU; 246638; -.
DR EnsemblMetazoa; FBtr0087439; FBpp0086569; FBgn0050476.
DR GeneID; 246638; -.
DR KEGG; dme:Dmel_CG30476; -.
DR UCSC; CG30476-RA; d. melanogaster.
DR CTD; 246638; -.
DR FlyBase; FBgn0050476; ave.
DR VEuPathDB; VectorBase:FBgn0050476; -.
DR eggNOG; ENOG502RXXU; Eukaryota.
DR GeneTree; ENSGT00390000008161; -.
DR HOGENOM; CLU_172777_0_0_1; -.
DR InParanoid; Q8ML92; -.
DR OMA; WREIMKL; -.
DR OrthoDB; 1479834at2759; -.
DR PhylomeDB; Q8ML92; -.
DR Reactome; R-DME-209190; Phosphorylation of CI.
DR Reactome; R-DME-209214; Phosphorylation of SMO.
DR Reactome; R-DME-432553; Phosphorylation of PER and TIM.
DR SignaLink; Q8ML92; -.
DR BioGRID-ORCS; 246638; 2 hits in 3 CRISPR screens.
DR EvolutionaryTrace; Q8ML92; -.
DR GenomeRNAi; 246638; -.
DR PRO; PR:Q8ML92; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0050476; Expressed in antenna and 23 other tissues.
DR ExpressionAtlas; Q8ML92; baseline and differential.
DR Genevisible; Q8ML92; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:FlyBase.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0097110; F:scaffold protein binding; IPI:FlyBase.
DR GO; GO:0042675; P:compound eye cone cell differentiation; IMP:FlyBase.
DR GO; GO:0001751; P:compound eye photoreceptor cell differentiation; IMP:FlyBase.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IMP:UniProtKB.
DR GO; GO:0001754; P:eye photoreceptor cell differentiation; IMP:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:FlyBase.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; HGI:FlyBase.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IMP:FlyBase.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd09510; SAM_aveugle-like; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR039144; Aveugle-like_SAM_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Membrane; Reference proteome;
KW Sensory transduction; Vision.
FT CHAIN 1..106
FT /note="Protein aveugle"
FT /id="PRO_0000235297"
FT DOMAIN 26..91
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT HELIX 23..25
FT /evidence="ECO:0007829|PDB:3BS7"
FT HELIX 28..38
FT /evidence="ECO:0007829|PDB:3BS7"
FT HELIX 40..45
FT /evidence="ECO:0007829|PDB:3BS7"
FT HELIX 46..51
FT /evidence="ECO:0007829|PDB:3BS7"
FT HELIX 56..59
FT /evidence="ECO:0007829|PDB:3BS7"
FT HELIX 64..70
FT /evidence="ECO:0007829|PDB:3BS7"
FT HELIX 75..94
FT /evidence="ECO:0007829|PDB:3BS7"
SQ SEQUENCE 106 AA; 12783 MW; 7DB605A43989F997 CRC64;
MGEETINSTQ NKTRTKTTRP KAVYLWTVSD VLKWYRRHCG EYTQYEQLFA QHDITGRALL
RITDSSLQRM GVTDNRDREA IWREIVKQRL KTDIMEIRDM ERLNIY
