ID   AVFA_ASPFN              Reviewed;         282 AA.
AC   Q9P8Z9; B8NHY7;
DT   01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Averufin oxidase A;
DE            EC=1.-.-.-;
GN   Name=avfA; ORFNames=AFLA_139230;
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=10806361; DOI=10.1016/s0378-1119(00)00126-8;
RA   Yu J., Woloshuk C.P., Bhatnagar D., Cleveland T.E.;
RT   "Cloning and characterization of avfA and omtB genes involved in aflatoxin
RT   biosynthesis in three Aspergillus species.";
RL   Gene 248:157-167(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
CC   -!- FUNCTION: Involved in the conversion of averufin (AVF) to versiconal
CC       hemiacetal acetate (VHA) in the aflatoxin biosynthesis pathway.
CC       {ECO:0000269|PubMed:10806361}.
CC   -!- PATHWAY: Mycotoxin biosynthesis; aflatoxin biosynthesis.
CC       {ECO:0000269|PubMed:10806361}.
CC   -!- SIMILARITY: Belongs to the avfA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EED51158.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF159789; AAF26224.1; -; Genomic_DNA.
DR   EMBL; EQ963478; EED51158.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002379934.1; XM_002379893.1.
DR   AlphaFoldDB; Q9P8Z9; -.
DR   EnsemblFungi; EED51158; EED51158; AFLA_139230.
DR   eggNOG; ENOG502SM0C; Eukaryota.
DR   UniPathway; UPA00287; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0045122; P:aflatoxin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF13460; NAD_binding_10; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..282
FT                   /note="Averufin oxidase A"
FT                   /id="PRO_0000422197"
SQ   SEQUENCE   282 AA;  30550 MW;  49B6F19CD9D2192E CRC64;
     MVTYALLGAT GATGSSILRH LLHESPDSLR IQILVRSKVK LLQAFPNLQT TRNPQVHVIQ
     GTSTDPDALS ECLRNASIVF MCVAQNGSPI GTTLCQDSAR AIISVLQQQQ QSQGASYQPC
     TIVQLRSASL NPALAAQVPA FVHRIVSFCL FANYADIKKA CQYYSQAQKQ GILEYILVDP
     PTLHDANGTQ PTGYRLISTE SQATALSYAD LGAAMCEIAH RQSEFHGRAV GVTATGRVRQ
     AWGVLLRHLL EGGSARLREK IAQETVVDGV VFAFLVVLAY LM