AVH52_PHYSO
ID AVH52_PHYSO Reviewed; 122 AA.
AC G1FR37;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 16.
DE RecName: Full=RxLR effector protein Avh52 {ECO:0000303|PubMed:21653195};
DE AltName: Full=Avirulence homolog protein 52 {ECO:0000303|PubMed:21653195};
DE Flags: Precursor;
GN Name=Avh52 {ECO:0000303|PubMed:21653195};
OS Phytophthora sojae (Soybean stem and root rot agent) (Phytophthora
OS megasperma f. sp. glycines).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=67593;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, FUNCTION, INDUCTION, AND
RP DOMAIN.
RC STRAIN=P7064, P7074, and P7076;
RX PubMed=21653195; DOI=10.1105/tpc.111.086082;
RA Wang Q., Han C., Ferreira A.O., Yu X., Ye W., Tripathy S., Kale S.D.,
RA Gu B., Sheng Y., Sui Y., Wang X., Zhang Z., Cheng B., Dong S., Shan W.,
RA Zheng X., Dou D., Tyler B.M., Wang Y.;
RT "Transcriptional programming and functional interactions within the
RT Phytophthora sojae RXLR effector repertoire.";
RL Plant Cell 23:2064-2086(2011).
RN [2]
RP FUNCTION.
RX PubMed=26163574; DOI=10.1105/tpc.15.00390;
RA Ma Z., Song T., Zhu L., Ye W., Wang Y., Shao Y., Dong S., Zhang Z., Dou D.,
RA Zheng X., Tyler B.M., Wang Y.;
RT "A Phytophthora sojae glycoside hydrolase 12 protein is a major virulence
RT factor during soybean infection and is recognized as a PAMP.";
RL Plant Cell 27:2057-2072(2015).
RN [3]
RP FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH HOST TAP1, SUBCELLULAR
RP LOCATION, AND DOMAIN.
RX PubMed=30346270; DOI=10.7554/elife.40039;
RA Li H., Wang H., Jing M., Zhu J., Guo B., Wang Y., Lin Y., Chen H., Kong L.,
RA Ma Z., Wang Y., Ye W., Dong S., Tyler B., Wang Y.;
RT "A Phytophthora effector recruits a host cytoplasmic transacetylase into
RT nuclear speckles to enhance plant susceptibility.";
RL Elife 7:0-0(2018).
CC -!- FUNCTION: Effector that suppresses plant defense responses during the
CC early stages of pathogen infection (PubMed:21653195, PubMed:26163574,
CC PubMed:30346270). Suppresses cell death induced by effectors and PAMPs
CC in plant hosts (PubMed:26163574, PubMed:30346270). Interacts with host
CC acetyltransferase TAP1 and causes TAP1 relocation into the nucleus
CC where it acetylates histones H2A and H3 during early infection, thereby
CC promoting susceptibility of host plant to P.sojae (PubMed:30346270).
CC {ECO:0000269|PubMed:21653195, ECO:0000269|PubMed:26163574,
CC ECO:0000269|PubMed:30346270}.
CC -!- SUBUNIT: Interacts with host acetyl transferase TAP1.
CC {ECO:0000269|PubMed:30346270}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30346270}. Host
CC nucleus {ECO:0000269|PubMed:30346270}.
CC -!- INDUCTION: Expression is strongly up-regulated during the early stages
CC of infection. {ECO:0000269|PubMed:21653195}.
CC -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC phosphate. {ECO:0000305|PubMed:21653195}.
CC -!- DOMAIN: Residues 69 to 86 are required for the interaction with host
CC TAP1 and its re-localization into nuclear speckles.
CC {ECO:0000269|PubMed:30346270}.
CC -!- DOMAIN: The nuclear localization signal (NLS) is required for
CC localization into nucleus. {ECO:0000269|PubMed:30346270}.
CC -!- DISRUPTION PHENOTYPE: Leads to smaller lesions on soybean seedlings.
CC {ECO:0000269|PubMed:30346270}.
CC -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR EMBL; JN253760; AEK80573.1; -; Genomic_DNA.
DR EMBL; JN253761; AEK80574.1; -; Genomic_DNA.
DR EMBL; JN253762; AEK80575.1; -; Genomic_DNA.
DR AlphaFoldDB; G1FR37; -.
DR VEuPathDB; FungiDB:PHYSODRAFT_355041; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR031825; RXLR.
DR Pfam; PF16810; RXLR; 1.
PE 1: Evidence at protein level;
KW Host nucleus; Secreted; Signal; Virulence.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..122
FT /note="RxLR effector protein Avh52"
FT /id="PRO_5007659774"
FT REGION 69..86
FT /note="TAP1-binding"
FT /evidence="ECO:0000269|PubMed:30346270"
FT REGION 87..98
FT /note="Nuclear localization signal (NLS)"
FT /evidence="ECO:0000269|PubMed:30346270"
FT MOTIF 50..68
FT /note="RxLR-dEER"
FT /evidence="ECO:0000305|PubMed:30346270"
SQ SEQUENCE 122 AA; 13583 MW; E8802DA683101D16 CRC64;
MRLTSILVLV IAATFHTTGT ALTLTKDSKA GIANGDSPAS GDFIDANSAR LLRRVEKDKV
DYEQDEQRSF GALKDAVKKL NPVTAVKKFF KQRARRKKVI QTARNADDNL AWAMRKVYNE
AN
