ID   AVH6_PHYSO              Reviewed;         125 AA.
AC   G1FQR7;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=RxLR effector protein Avh6 {ECO:0000303|PubMed:23550527};
DE   AltName: Full=Avirulence homolog protein 6 {ECO:0000303|PubMed:23550527};
DE   AltName: Full=Avirulence protein 1d {ECO:0000303|PubMed:23550527};
DE   Flags: Precursor;
GN   Name=Avh6 {ECO:0000303|PubMed:21653195};
GN   Synonyms=Avh6-2 {ECO:0000303|PubMed:23550527},
GN   Avr1d {ECO:0000303|PubMed:23550527};
OS   Phytophthora sojae (Soybean stem and root rot agent) (Phytophthora
OS   megasperma f. sp. glycines).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=67593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, FUNCTION, INDUCTION, AND
RP   DOMAIN.
RC   STRAIN=P7064;
RX   PubMed=21653195; DOI=10.1105/tpc.111.086082;
RA   Wang Q., Han C., Ferreira A.O., Yu X., Ye W., Tripathy S., Kale S.D.,
RA   Gu B., Sheng Y., Sui Y., Wang X., Zhang Z., Cheng B., Dong S., Shan W.,
RA   Zheng X., Dou D., Tyler B.M., Wang Y.;
RT   "Transcriptional programming and functional interactions within the
RT   Phytophthora sojae RXLR effector repertoire.";
RL   Plant Cell 23:2064-2086(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE,
RP   PTDINS(4)P-BINDING, AND MUTAGENESIS OF 48-ARG--ARG-51.
RC   STRAIN=P7064;
RX   PubMed=23550527; DOI=10.1094/mpmi-02-13-0036-r;
RA   Na R., Yu D., Qutob D., Zhao J., Gijzen M.;
RT   "Deletion of the Phytophthora sojae avirulence gene Avr1d causes gain of
RT   virulence on Rps1d.";
RL   Mol. Plant Microbe Interact. 26:969-976(2013).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=23594349; DOI=10.1094/mpmi-02-13-0035-r;
RA   Yin W., Dong S., Zhai L., Lin Y., Zheng X., Wang Y.;
RT   "The Phytophthora sojae Avr1d gene encodes an RxLR-dEER effector with
RT   presence and absence polymorphisms among pathogen strains.";
RL   Mol. Plant Microbe Interact. 26:958-968(2013).
CC   -!- FUNCTION: Effector that suppresses plant defense responses during the
CC       early stages of pathogen infection. Suppresses cell death induced by
CC       effectors and PAMPs in plant hosts (PubMed:21653195, PubMed:23550527).
CC       Triggers a hypersensitive response (HR) in the presence of Rps1d
CC       (PubMed:23550527, PubMed:23594349). Suppresses BAX-induced cell death
CC       and enhanced P.capsici infection in Nicotiana benthamiana. Also
CC       suppresses effector-triggered immunity induction by associating with
CC       Avr1b and Rps1b, suggesting a role in suppressing plant immunity
CC       (PubMed:23594349). {ECO:0000269|PubMed:21653195,
CC       ECO:0000269|PubMed:23550527, ECO:0000269|PubMed:23594349}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21653195}. Host cell
CC       {ECO:0000305|PubMed:21653195}.
CC   -!- INDUCTION: Expression is strongly up-regulated during the early stages
CC       of infection. {ECO:0000269|PubMed:21653195,
CC       ECO:0000269|PubMed:23594349}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:21653195}.
CC   -!- DISRUPTION PHENOTYPE: Leads to the gain of virulence via impairing
CC       effector-triggered immunity (ETI) allowed by host resistance (R)
CC       protein Rps1d. {ECO:0000269|PubMed:23550527}.
CC   -!- MISCELLANEOUS: Avh6 is present in P.sojae strains that are avirulent on
CC       Rps1d hosts, whereas the gene is deleted from the genome of virulent
CC       strains. {ECO:0000305|PubMed:23550527}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; JN253642; AEK80455.1; -; Genomic_DNA.
DR   EMBL; KC004058; AGC92779.1; -; Genomic_DNA.
DR   AlphaFoldDB; G1FQR7; -.
DR   VEuPathDB; FungiDB:PHYSODRAFT_354880; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031825; RXLR.
DR   Pfam; PF16810; RXLR; 1.
PE   1: Evidence at protein level;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..125
FT                   /note="RxLR effector protein Avh6"
FT                   /id="PRO_5007659748"
FT   MOTIF           48..70
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:21653195"
SQ   SEQUENCE   125 AA;  13904 MW;  A73E2066CC722865 CRC64;
     MRLSSTTFVV LAAVLLASGT AVSKADETGV TNVNAVHSPN VLAGVDKRFL RSHHTEDGKA
     KLSNYDNEER NGLFAAGTLS DMANDMIFRF KMFTKWKANG HLPKAIKKDI PRSLYKAYKI
     HHRMN