AB7G_ARATH
ID AB7G_ARATH Reviewed; 725 AA.
AC Q9ZU35; Q3EC89; Q9ASR9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=ABC transporter G family member 7;
DE Short=ABC transporter ABCG.7;
DE Short=AtABCG7;
DE AltName: Full=White-brown complex homolog protein 7;
DE Short=AtWBC7;
GN Name=ABCG7; Synonyms=WBC7; OrderedLocusNames=At2g01320; ORFNames=F10A8.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ZU35-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ZU35-2; Sequence=VSP_019426;
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC006200; AAD14532.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05433.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05434.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05435.1; -; Genomic_DNA.
DR EMBL; AF367318; AAK32905.1; -; mRNA.
DR EMBL; AY133617; AAM91447.1; -; mRNA.
DR PIR; C84423; C84423.
DR RefSeq; NP_178241.1; NM_126193.3. [Q9ZU35-1]
DR RefSeq; NP_849922.1; NM_179591.2. [Q9ZU35-2]
DR RefSeq; NP_973392.1; NM_201663.1. [Q9ZU35-1]
DR AlphaFoldDB; Q9ZU35; -.
DR SMR; Q9ZU35; -.
DR BioGRID; 64; 1.
DR STRING; 3702.AT2G01320.3; -.
DR TCDB; 3.A.1.204.41; the atp-binding cassette (abc) superfamily.
DR iPTMnet; Q9ZU35; -.
DR PaxDb; Q9ZU35; -.
DR PRIDE; Q9ZU35; -.
DR ProteomicsDB; 245145; -. [Q9ZU35-1]
DR EnsemblPlants; AT2G01320.1; AT2G01320.1; AT2G01320. [Q9ZU35-1]
DR EnsemblPlants; AT2G01320.3; AT2G01320.3; AT2G01320. [Q9ZU35-2]
DR EnsemblPlants; AT2G01320.4; AT2G01320.4; AT2G01320. [Q9ZU35-1]
DR GeneID; 814660; -.
DR Gramene; AT2G01320.1; AT2G01320.1; AT2G01320. [Q9ZU35-1]
DR Gramene; AT2G01320.3; AT2G01320.3; AT2G01320. [Q9ZU35-2]
DR Gramene; AT2G01320.4; AT2G01320.4; AT2G01320. [Q9ZU35-1]
DR KEGG; ath:AT2G01320; -.
DR Araport; AT2G01320; -.
DR TAIR; locus:2038746; AT2G01320.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_9_1; -.
DR InParanoid; Q9ZU35; -.
DR PhylomeDB; Q9ZU35; -.
DR PRO; PR:Q9ZU35; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZU35; baseline and differential.
DR Genevisible; Q9ZU35; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..725
FT /note="ABC transporter G family member 7"
FT /id="PRO_0000240679"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 70..316
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 392..603
FT /note="ABC transmembrane type-2"
FT REGION 676..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..710
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 108..115
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT VAR_SEQ 724..725
FT /note="GL -> AGSKV (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_019426"
FT CONFLICT 672
FT /note="G -> R (in Ref. 3; AAK32905/AAM91447)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 725 AA; 78899 MW; 7DB2E556FE3553D7 CRC64;
MAPFGGKSLA DVVSGIGGNG VGGALAAVAA ALLVRLFAGP GIALLPEDEA EDDYAETEDG
GGDSIRPVTI RWRNITCSLS DKSSKSVRFL LKNVSGEAKP GRLLAIMGPS GSGKTTLLNV
LAGQLSLSPR LHLSGLLEVN GKPSSSKAYK LAFVRQEDLF FSQLTVRETL SFAAELQLPE
ISSAEERDEY VNNLLLKLGL VSCADSCVGD AKVRGISGGE KKRLSLACEL IASPSVIFAD
EPTTGLDAFQ AEKVMETLQK LAQDGHTVIC SIHQPRGSVY AKFDDIVLLT EGTLVYAGPA
GKEPLTYFGN FGFLCPEHVN PAEFLADLIS VDYSSSETVY SSQKRVHALV DAFSQRSSSV
LYATPLSMKE ETKNGMRPRR KAIVERTDGW WRQFFLLLKR AWMQASRDGP TNKVRARMSV
ASAVIFGSVF WRMGKSQTSI QDRMGLLQVA AINTAMAALT KTVGVFPKER AIVDRERSKG
SYSLGPYLLS KTIAEIPIGA AFPLMFGAVL YPMARLNPTL SRFGKFCGIV TVESFAASAM
GLTVGAMVPS TEAAMAVGPS LMTVFIVFGG YYVNADNTPI IFRWIPRASL IRWAFQGLCI
NEFSGLKFDH QNTFDVQTGE QALERLSFGG RRIRETIAAQ SRILMFWYSA TYLLLEKNKP
KYQKLELLVD NGETGNSGVQ LDKAEVDQTE KPEDDDINQP LDDQNQTSDS DDELDEIRPF
VLEGL
