AVL9_MOUSE
ID AVL9_MOUSE Reviewed; 649 AA.
AC Q80U56; Q149B3;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Late secretory pathway protein AVL9 homolog;
GN Name=Avl9; Synonyms=Kiaa0241;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Functions in cell migration. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250}. Membrane
CC {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AVL9 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC65510.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK122228; BAC65510.1; ALT_INIT; mRNA.
DR EMBL; BC117878; AAI17879.1; -; mRNA.
DR CCDS; CCDS51789.1; -.
DR RefSeq; NP_084511.1; NM_030235.1.
DR AlphaFoldDB; Q80U56; -.
DR STRING; 10090.ENSMUSP00000031805; -.
DR iPTMnet; Q80U56; -.
DR PhosphoSitePlus; Q80U56; -.
DR SwissPalm; Q80U56; -.
DR EPD; Q80U56; -.
DR jPOST; Q80U56; -.
DR MaxQB; Q80U56; -.
DR PaxDb; Q80U56; -.
DR PeptideAtlas; Q80U56; -.
DR PRIDE; Q80U56; -.
DR ProteomicsDB; 277139; -.
DR Antibodypedia; 53032; 83 antibodies from 15 providers.
DR Ensembl; ENSMUST00000031805; ENSMUSP00000031805; ENSMUSG00000029787.
DR GeneID; 78937; -.
DR KEGG; mmu:78937; -.
DR UCSC; uc009cbl.2; mouse.
DR CTD; 23080; -.
DR MGI; MGI:1926187; Avl9.
DR VEuPathDB; HostDB:ENSMUSG00000029787; -.
DR eggNOG; KOG3823; Eukaryota.
DR GeneTree; ENSGT00390000010255; -.
DR HOGENOM; CLU_009066_2_1_1; -.
DR InParanoid; Q80U56; -.
DR OMA; NDHFNAH; -.
DR OrthoDB; 1184841at2759; -.
DR PhylomeDB; Q80U56; -.
DR TreeFam; TF105998; -.
DR BioGRID-ORCS; 78937; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Avl9; mouse.
DR PRO; PR:Q80U56; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q80U56; protein.
DR Bgee; ENSMUSG00000029787; Expressed in metanephric cortical collecting duct and 242 other tissues.
DR ExpressionAtlas; Q80U56; baseline and differential.
DR Genevisible; Q80U56; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR InterPro; IPR018307; ABL9/DENND6_dom.
DR InterPro; IPR037516; Tripartite_DENN.
DR Pfam; PF09794; Avl9; 1.
DR PROSITE; PS50211; DENN; 1.
PE 1: Evidence at protein level;
KW Endosome; Membrane; Methylation; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..649
FT /note="Late secretory pathway protein AVL9 homolog"
FT /id="PRO_0000247179"
FT TRANSMEM 204..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 17..161
FT /note="uDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 173..341
FT /note="cDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT DOMAIN 343..594
FT /note="dDENN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT REGION 239..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 244
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 589
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8NBF6"
SQ SEQUENCE 649 AA; 72186 MW; B95EC289580D610F CRC64;
MEKSGRESDG APCGPVLHIV VVGFHHKKGC QVEFSYPPLI PGDGHDSHTL PEEWKYLPFL
ALPDGAHNYQ EDTVFFHLPP RNGNGATVYG ISCYRQIEAK ALKVRQADIT RETVQKSVCV
LSKLPLYGLL QAKLQLITHA YFEEKDFSQI SILKELYEHM NSSLGGASLE GSQVYLGLSP
RDLVLHFRHK VLILFKLILL EKKVLFYISP VNRLVGALMT VLSLFPGMIE HGLSDCSQYR
PRKSMSEDAG PQESNPSADD FTSESTSDVL NTSLETVTRV MAVNHGEDAV PKTEKPYFQV
EGNNNKGQEP SDSGRYLELP PRPSPESSES DWETLDPSVL EDASLKEREQ MGSDQTHLFQ
KDSLPSDSPP ITVQPQANNR QVVLIPGLIS GLEEDQYGMP LAIFTKGYLC LPYMALQQHH
LLSDVTVRGF VAGATNILFR QQKHLSDAIV EVEEALIQIH DPELRKLLNP TTADLRFADY
LVRHVTENRD DVFLDGTGWE GGDEWIRAQF AVYIHALLAA TLQLDNEKML SDYGTTFVAA
WKNTHNYRVW NSNKHPALSE INPNHPFQGQ YSVSDMKLRF SHSVQNSERG KKIGSVMVTT
SRNVVQTGKA VGQSVGGAFS SAKTAMSSWL STFTTSTPQS LPEPPNGKP
