ID   AVL9_PONAB              Reviewed;         630 AA.
AC   Q5R991;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Late secretory pathway protein AVL9 homolog;
GN   Name=AVL9;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in cell migration. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250}. Membrane
CC       {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AVL9 family. {ECO:0000305}.
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DR   EMBL; CR859500; CAH91669.1; -; mRNA.
DR   RefSeq; NP_001125979.1; NM_001132507.1.
DR   AlphaFoldDB; Q5R991; -.
DR   STRING; 9601.ENSPPYP00000019795; -.
DR   GeneID; 100172917; -.
DR   KEGG; pon:100172917; -.
DR   CTD; 23080; -.
DR   eggNOG; KOG3823; Eukaryota.
DR   InParanoid; Q5R991; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
DR   GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR   InterPro; IPR018307; ABL9/DENND6_dom.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   Pfam; PF09794; Avl9; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane; Methylation; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..630
FT                   /note="Late secretory pathway protein AVL9 homolog"
FT                   /id="PRO_0000247180"
FT   TRANSMEM        214..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          17..161
FT                   /note="uDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          173..340
FT                   /note="cDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          342..575
FT                   /note="dDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   REGION          299..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..372
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         244
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80U56"
FT   MOD_RES         570
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NBF6"
SQ   SEQUENCE   630 AA;  69642 MW;  39846F9D5730B71E CRC64;
     MEKARRGGDG VPRGPVLHIV VVGFHHKKGC QVEFSYPPLI PGDGHDSHTL PEEWKYLPFL
     ALPDGAHNYQ EDTVFFHLPP RNGNGATVFG ISCYRQIEAK ALKVRQADIT RETVQKSVCV
     LSKLPLYGLL QAKLQLITHA YFEEKDFSQI SILKELYEHM NSSLGGASLE GSQVYLGLSP
     RDLVLHFRHK VLILFKLILL EKKVLFYISP VNKLVGALMT VLSLFPGMIE HGLSDCSQYR
     PRKSMSEDGG LQESNPCADD FVSASTADVS HTNLGTVRKV IAGNHGEDAA MKTEEPLFQV
     EDSSKGQEPN DTNQYLKPPS RPSPDSSESD WETLDPSVLE DPNSKEREQL GSDQTNLFPK
     DSVPSESLPI TVQPQANTGQ VVLIPGLISG LEEDQYGMPL AIFTKGYLCL PYMALQQHHL
     LSDVTVRGFV AGATNILFRQ QKHLGDAIVE VEEALIQIHD PELRKLLNPT TADLRFADYL
     VRHVTENRDD VFLDGTGWEG GDEWIRAQFA VYIHALLAAT LQLDNEKILS DYGTTFVTAW
     KNTHDYRVWN SNKHPALAEI NPNSVQNSER GKKIGNVMVT TSRNVVQTGK AVGQSVGGAF
     SSAKTAMSSW LSTFTTSTSQ SLTEPPDGKP