ID   AVL9_SCHPO              Reviewed;         469 AA.
AC   O13943;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Late secretory pathway protein avl9;
GN   Name=avl9; ORFNames=SPAC23H3.14;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Functions in the late secretory pathway. Required for the
CC       generation of secretory vesicles as well as for actin polarization and
CC       polarized growth (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the AVL9 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB16239.2; -; Genomic_DNA.
DR   PIR; T38307; T38307.
DR   RefSeq; NP_593804.1; NM_001019233.2.
DR   AlphaFoldDB; O13943; -.
DR   STRING; 4896.SPAC23H3.14.1; -.
DR   MaxQB; O13943; -.
DR   PaxDb; O13943; -.
DR   PRIDE; O13943; -.
DR   EnsemblFungi; SPAC23H3.14.1; SPAC23H3.14.1:pep; SPAC23H3.14.
DR   GeneID; 2541794; -.
DR   KEGG; spo:SPAC23H3.14; -.
DR   PomBase; SPAC23H3.14; avl9.
DR   VEuPathDB; FungiDB:SPAC23H3.14; -.
DR   eggNOG; KOG3823; Eukaryota.
DR   HOGENOM; CLU_009066_3_1_1; -.
DR   InParanoid; O13943; -.
DR   OMA; NDHFNAH; -.
DR   PhylomeDB; O13943; -.
DR   PRO; PR:O13943; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0005768; C:endosome; ISS:PomBase.
DR   GO; GO:0006892; P:post-Golgi vesicle-mediated transport; ISO:PomBase.
DR   InterPro; IPR018307; ABL9/DENND6_dom.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   Pfam; PF09794; Avl9; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..469
FT                   /note="Late secretory pathway protein avl9"
FT                   /id="PRO_0000353134"
FT   DOMAIN          11..150
FT                   /note="uDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          163..332
FT                   /note="cDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          334..437
FT                   /note="dDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
SQ   SEQUENCE   469 AA;  53116 MW;  49448C181229D1F3 CRC64;
     MDENGASFQV LCLATIGFHH LRGPEIEHLF PESMDFPKEW SILPFLSLPD GAHSSEKDFV
     YFTLPFPNDE GTVFGLSCTR QLNASSLKNI PSDVTRSSVQ KAVVVITTSP PFGHIKDNLD
     IVTNAYFSQG DFSNLDVLRD FFHVLTRKEQ DVHIALNINL KSFLCEWRQN ALVLLKVLLL
     GKRILVYDKS AERLGNFQYS LLSLIPCMMS HLQDVSSPSA HSLEKSLHKP ASLQTSDKRS
     LLAYTGFPLI IFGEGSMFSP YTPLQLVHVL EAKSSTSWLA GTTNTLIMLN QNKMAEVIVR
     SDTHQIEFVD PTIKNLTSLT YTDKSWMEDI ISRVESSLEM ELPGFEGSDD WIRNQFELYI
     FGMLATVKYY NFLKKQDDSI LSQYHYLPST SCISDYGETF LLEWMKTNTF RIWNNIADDD
     LFDVILPKHP CKEEHKVPIS ARIATLFSAV KITPKSRDGE DEGSKEPAV