ID   RRAB_SALTY              Reviewed;         138 AA.
AC   P0A1U6; Q08019;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Regulator of ribonuclease activity B {ECO:0000255|HAMAP-Rule:MF_01888};
GN   Name=rraB {ECO:0000255|HAMAP-Rule:MF_01888}; OrderedLocusNames=STM4470;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=8253666; DOI=10.1128/jb.175.24.7776-7785.1993;
RA   Persson B.C., Bjoerk G.R.;
RT   "Isolation of the gene (miaE) encoding the hydroxylase involved in the
RT   synthesis of 2-methylthio-cis-ribozeatin in tRNA of Salmonella typhimurium
RT   and characterization of mutants.";
RL   J. Bacteriol. 175:7776-7785(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Globally modulates RNA abundance by binding to RNase E (Rne)
CC       and regulating its endonucleolytic activity. Can modulate Rne action in
CC       a substrate-dependent manner by altering the composition of the
CC       degradosome. {ECO:0000255|HAMAP-Rule:MF_01888}.
CC   -!- SUBUNIT: Interacts with the C-terminal region of Rne.
CC       {ECO:0000255|HAMAP-Rule:MF_01888}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01888}.
CC   -!- SIMILARITY: Belongs to the RraB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01888}.
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DR   EMBL; X73368; CAA51781.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL23289.1; -; Genomic_DNA.
DR   PIR; S34360; S34360.
DR   RefSeq; NP_463330.1; NC_003197.2.
DR   RefSeq; WP_000002940.1; NC_003197.2.
DR   AlphaFoldDB; P0A1U6; -.
DR   SMR; P0A1U6; -.
DR   STRING; 99287.STM4470; -.
DR   PaxDb; P0A1U6; -.
DR   EnsemblBacteria; AAL23289; AAL23289; STM4470.
DR   GeneID; 1255996; -.
DR   KEGG; stm:STM4470; -.
DR   PATRIC; fig|99287.12.peg.4705; -.
DR   HOGENOM; CLU_128640_0_0_6; -.
DR   OMA; FCFDAIA; -.
DR   PhylomeDB; P0A1U6; -.
DR   BioCyc; SENT99287:STM4470-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0060698; F:endoribonuclease inhibitor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019899; F:enzyme binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.970; -; 1.
DR   HAMAP; MF_01888; RraB; 1.
DR   InterPro; IPR016716; RraB.
DR   InterPro; IPR036701; RraB-like_sf.
DR   InterPro; IPR009671; RraB_dom.
DR   Pfam; PF06877; RraB; 1.
DR   PIRSF; PIRSF018193; UCP018193; 1.
DR   SUPFAM; SSF89946; SSF89946; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..138
FT                   /note="Regulator of ribonuclease activity B"
FT                   /id="PRO_0000169762"
FT   REGION          111..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   138 AA;  15697 MW;  6104405A703379E1 CRC64;
     MANPELLEEQ REETRLIIEE LLEDGSDPDA LYTIEHHLSA DDFETLEKAA VEAFKLGYEV
     TEPEELEVEE GDTVICCDIL SECALNAELI DAQVEQLMNL AEKYDVEYDG WGTYFEDPNG
     EEGDDDDYVD EDDDGVRH