RRAB_SHIFL
ID RRAB_SHIFL Reviewed; 138 AA.
AC P0AF92; P37163;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Regulator of ribonuclease activity B {ECO:0000255|HAMAP-Rule:MF_01888};
GN Name=rraB {ECO:0000255|HAMAP-Rule:MF_01888};
GN OrderedLocusNames=SF4234, S4495;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Globally modulates RNA abundance by binding to RNase E (Rne)
CC and regulating its endonucleolytic activity. Can modulate Rne action in
CC a substrate-dependent manner by altering the composition of the
CC degradosome. {ECO:0000255|HAMAP-Rule:MF_01888}.
CC -!- SUBUNIT: Interacts with the C-terminal region of Rne.
CC {ECO:0000255|HAMAP-Rule:MF_01888}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01888}.
CC -!- SIMILARITY: Belongs to the RraB family. {ECO:0000255|HAMAP-
CC Rule:MF_01888}.
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DR EMBL; AE005674; AAN45653.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP19440.1; -; Genomic_DNA.
DR RefSeq; NP_709946.1; NC_004337.2.
DR RefSeq; WP_000002953.1; NZ_WPGW01000270.1.
DR AlphaFoldDB; P0AF92; -.
DR SMR; P0AF92; -.
DR STRING; 198214.SF4234; -.
DR PRIDE; P0AF92; -.
DR EnsemblBacteria; AAN45653; AAN45653; SF4234.
DR EnsemblBacteria; AAP19440; AAP19440; S4495.
DR GeneID; 1026832; -.
DR GeneID; 66671826; -.
DR KEGG; sfl:SF4234; -.
DR KEGG; sfx:S4495; -.
DR PATRIC; fig|198214.7.peg.4994; -.
DR HOGENOM; CLU_128640_0_0_6; -.
DR OMA; FCFDAIA; -.
DR OrthoDB; 1479816at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0060698; F:endoribonuclease inhibitor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019899; F:enzyme binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.970; -; 1.
DR HAMAP; MF_01888; RraB; 1.
DR InterPro; IPR016716; RraB.
DR InterPro; IPR036701; RraB-like_sf.
DR InterPro; IPR009671; RraB_dom.
DR Pfam; PF06877; RraB; 1.
DR PIRSF; PIRSF018193; UCP018193; 1.
DR SUPFAM; SSF89946; SSF89946; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..138
FT /note="Regulator of ribonuclease activity B"
FT /id="PRO_0000169763"
FT REGION 114..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 138 AA; 15603 MW; E23D6DBE6547FD0F CRC64;
MANPEQLEEQ REETRLIIEE LLEDGSDPDA LYTIEHHLSA DDLETLEKAA VEAFKLGYEV
TDPEELEVED GDIVICCDIL SECALNADLI DAQVEQLMTL AEKFDVEYDG WGTYFEDPNG
EDGDDEDFVD EDDDGVRH
