AB8A_ARATH
ID AB8A_ARATH Reviewed; 901 AA.
AC Q8LPK0; Q9STT4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=ABC transporter A family member 8;
DE Short=ABC transporter ABCA.8;
DE Short=AtABCA8;
DE AltName: Full=ABC2 homolog 7;
GN Name=ABCA8; Synonyms=ATH7; OrderedLocusNames=At3g47790; ORFNames=T23J7.120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB41862.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049746; CAB41862.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78329.1; -; Genomic_DNA.
DR EMBL; AY099665; AAM20516.1; -; mRNA.
DR PIR; T07718; T07718.
DR RefSeq; NP_190363.3; NM_114647.4.
DR AlphaFoldDB; Q8LPK0; -.
DR SMR; Q8LPK0; -.
DR STRING; 3702.AT3G47790.1; -.
DR PaxDb; Q8LPK0; -.
DR PRIDE; Q8LPK0; -.
DR ProteomicsDB; 244617; -.
DR EnsemblPlants; AT3G47790.1; AT3G47790.1; AT3G47790.
DR GeneID; 823933; -.
DR Gramene; AT3G47790.1; AT3G47790.1; AT3G47790.
DR KEGG; ath:AT3G47790; -.
DR Araport; AT3G47790; -.
DR TAIR; locus:2100337; AT3G47790.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_5_1; -.
DR InParanoid; Q8LPK0; -.
DR OMA; FPKEINC; -.
DR OrthoDB; 130188at2759; -.
DR BioCyc; ARA:AT3G47790-MON; -.
DR PRO; PR:Q8LPK0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8LPK0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..901
FT /note="ABC transporter A family member 8"
FT /id="PRO_0000240329"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 586..823
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 624..631
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 427
FT /note="T -> I (in Ref. 1; CAB41862)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 901 AA; 101337 MW; 1605A96BBFFE806D CRC64;
MADSSPASFL TQADALLRKN LVFQKRNIWS NIRLITIPFF LCLLLLVIQM LFDTQFNDVH
GQCGCNEKTC GLRYSTSEQA AFCAIPNPPQ WTPLLQIPAP EYRAAIPYPS HTSPATFLFT
GNNQSLGNIL MGNMYSNSSG FDGDLAYYVL GSSSFPAYTN HMDSAFISDL PIYNIQHECS
PNSSFSILIH QSPLAFPKEV NCVQGLNLWR NSSSDVNNEL FKGYRKGNPD KKINEFAGAF
DFQNTNGNNL NVSVWYNSTY KNDTVVRPMA LIRVPRLVNL ASNAYLEFLK GSETKILFEY
VKEMPKPETK LSLDIASLIG PLFFTWVILL LFPVILTTLV YEKQQRLRIM MKMHGLGDVP
YWIVSYTYFL LISILYMLCF AIFGSLIGLN FFRLNDYSIQ LVFFFICINL QISVAFLASA
MFSDVKTATV IAYIYVFGTG LLGIFLFQFF LEDPLFPRGW IIAMELYPGF SLYRGLYELS
QSAFAGDYRG IDGMKWRDFG NGMKEVTCIM LIEWLLLLGL AYYIDQIIYS RKHPLFFLLQ
STSKKKQHFS DNKISKVVVE MEKPDVCRER EKVEQCLLKS TRDSAVLCNN LKKVYSGKDG
NPQKLAVRGL SLALPQGECF GMLGPNGAGK TSFINMMTGI IKPSSGTAFV QGLDILTDMD
RIYTTIGVCP QHDLLWEKLS GREHLLFYGR LKNLKGSVLT QAVEESLRSV NLFHGGIGDK
QVSKYSGGMK RRLSVAISLI GSPKVVYMDE PSTGLDPASR KSLWDVVKRA KRKGAIILTT
HSMEEAEILC DRIGIFVDGS LQCIGNPKEL KSRYGGSYVL TVTTSEEHEK EVEQLVHNIS
TNAKKIYRTA GTQKFELPKQ EVKIGEVFKA LEKAKTMFPV VAWGLADTTL EDVFIKVAQT
S
