RRB1_SCHPO
ID RRB1_SCHPO Reviewed; 480 AA.
AC Q9P783;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Ribosome assembly protein rrb1;
GN Name=rrb1; ORFNames=SPBC1711.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163 AND SER-166, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Involved in regulation of L3 expression and stability and
CC plays a role in early 60S ribosomal subunit assembly. May be required
CC for proper assembly of pre-ribosomal particles during early ribosome
CC biogenesis, presumably by targeting L3 onto the 35S precursor rRNA (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with ribosomal protein L3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329671; CAB88237.1; -; Genomic_DNA.
DR RefSeq; NP_595880.1; NM_001021786.2.
DR AlphaFoldDB; Q9P783; -.
DR SMR; Q9P783; -.
DR BioGRID; 276247; 3.
DR STRING; 4896.SPBC1711.07.1; -.
DR iPTMnet; Q9P783; -.
DR MaxQB; Q9P783; -.
DR PaxDb; Q9P783; -.
DR PRIDE; Q9P783; -.
DR EnsemblFungi; SPBC1711.07.1; SPBC1711.07.1:pep; SPBC1711.07.
DR GeneID; 2539693; -.
DR KEGG; spo:SPBC1711.07; -.
DR PomBase; SPBC1711.07; rrb1.
DR VEuPathDB; FungiDB:SPBC1711.07; -.
DR eggNOG; KOG0302; Eukaryota.
DR HOGENOM; CLU_025272_1_1_1; -.
DR InParanoid; Q9P783; -.
DR OMA; DWSPLQP; -.
DR PhylomeDB; Q9P783; -.
DR PRO; PR:Q9P783; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005730; C:nucleolus; ISS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0042254; P:ribosome biogenesis; ISS:PomBase.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..480
FT /note="Ribosome assembly protein rrb1"
FT /id="PRO_0000316544"
FT REPEAT 183..225
FT /note="WD 1"
FT REPEAT 289..329
FT /note="WD 2"
FT REPEAT 334..375
FT /note="WD 3"
FT REPEAT 385..425
FT /note="WD 4"
FT REPEAT 446..480
FT /note="WD 5"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..62
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 480 AA; 53834 MW; FDC4DF882C831BA6 CRC64;
MSKRAAEETV EFNSKNGPGQ RGTVADNVDT EMGEFEDAYE DEIESEEEYI EADGEKDNGM
DEEEQNDAQP SKIPWLPGGK INADEKLVAD PSVYEMLHNI QVKWPFLSFD ILQDSLGEER
RAWPHQMYLV GGSQALDSND NELTVMKLSQ LYKTQHDEND DASDNSDVEE DPILEHKSIS
TKGACNRVRS ARRPANSSKE SLLASFHETG KVHIWDIAPH LRSLDSPGVM VSRKENSPLY
TVNRHKTEGY ALDWSPFEYS LLSGDNANEI FLTKYSNGGW QTDSSPFLSH TAAVEDLQWS
PSEKNVFSSC SCDGTFRIWD VRNKQKTSAL TVNAHPGVDV NVLSWNTRVP NLLATGADNG
VWSVWDLRSL KSSSSVATPV ASFKWHRAPI YSIEWHPNED SVIGVVGADN QISLWDLSVE
LDEEEQDSRA AEGLQDVPPQ LMFIHMGQQE IKEMHWHRQI PGTIVSTAMT GINVFKTITF
