ID   RRC1_CAEBR              Reviewed;         752 AA.
AC   A8WRJ2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=GTPase-activating protein rrc-1 {ECO:0000250|UniProtKB:Q20498};
DE   AltName: Full=RhoGAP for Rac-1 and Cdc-42 {ECO:0000250|UniProtKB:Q20498};
GN   Name=rrc-1 {ECO:0000312|EMBL:CAP23100.2}; ORFNames=CBG01901;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP23100.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP23100.2};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Functions as a GTPase-activating protein (GAP) for ced-
CC       10/RAC-1 and CDC42. {ECO:0000250|UniProtKB:Q20498}.
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DR   EMBL; HE601451; CAP23100.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WRJ2; -.
DR   SMR; A8WRJ2; -.
DR   STRING; 6238.CBG01901; -.
DR   PRIDE; A8WRJ2; -.
DR   WormBase; CBG01901a; CBP38656; WBGene00025070; Cbr-rrc-1.
DR   eggNOG; KOG1449; Eukaryota.
DR   HOGENOM; CLU_021271_0_0_1; -.
DR   InParanoid; A8WRJ2; -.
DR   OMA; ARRYMTT; -.
DR   OrthoDB; 279430at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Reference proteome; SH3 domain.
FT   CHAIN           1..752
FT                   /note="GTPase-activating protein rrc-1"
FT                   /id="PRO_0000370748"
FT   DOMAIN          165..244
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          281..463
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          523..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   752 AA;  85808 MW;  66077ACCB5FE6FF0 CRC64;
     MIDGVEESDA PLSPKSPFAR RNGRSLRIQR LVDCQHFHYT TVELGPVKVV IIAINTDENA
     TERIKMRVES ESNSWLVERS REDWAVFDRQ LHRCVFERRH SRLDELFPLI HLESAKFEEV
     LVKYTERLSE LTGSIITCYP VLKFLEIDSR GGHFEPAEET SINVPAIAAA VVTKDFEPTD
     NSQLRLRVGD IVSITEMSTA SPNEQTFWKA KLTISNQKIV DPQNGHLGFE IGYFPRDCVM
     LIDDKRLPNP LNTEPKPAPR NARRYMTTMF RNRRREPIFG LELTELFMRT GKRVPVIVER
     CCAAIEDQGI VTGIYRQCGI QSNIQRLRAK FDSGAEPDLH EFGQRDIYSV SSLLKQYFRQ
     LPNPLFTYQA YPALIETFEK EESVEEKVES LRFLLEAMPE HLSRLCKSKS LTDMTSKNLA
     IVWSPNLFRP PPTLNGADAH LLSGLNVHTA ICDFCIENSD SLFICDIDEE QSKCTSIENS
     FTTISKSATM SDMRSESDSR WPRFFRGKSV EGFWKFNRKQ QTSTGELCGS PPSEVKWRSR
     STRSHSTDAT FQSSRADSFM QLMHTGMDQI REGMRIFRAR ARSMRPTSRP PPSPRTRRAR
     FSNGGGANNV QRVNERERDI QIELPLATAE SSITPEPRST MDSNNIMTRT VSVNDSDDAS
     FEENGLKEIR ERKVMFKAAT QEHVAPIHER SSPVEEWSSD SRESLHLEMS RYDNVSPSGT
     ITRSQREPIS NLSPAAQLLF FESSRASQLF SA