RREB1_CHICK
ID RREB1_CHICK Reviewed; 1615 AA.
AC O57415; Q9I861;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Ras-responsive element-binding protein 1;
DE Short=RREB-1;
GN Name=RREB1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=9427563; DOI=10.1016/s0378-1119(97)00491-5;
RA Miyake J.H., Szeto D.P., Stumph W.E.;
RT "Analysis of the structure and expression of the chicken gene encoding a
RT homolog of the human RREB-1 transcription factor.";
RL Gene 202:177-186(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 745-938, AND VARIANTS SER-837 AND CYS-932.
RC STRAIN=Fayoumi, and Leghorn; TISSUE=Spleen;
RX PubMed=11261557; DOI=10.1093/ps/80.3.284;
RA Zhou H., Liu W., Lamont S.J.;
RT "Genetic variation among chicken lines and mammalian species in specific
RT genes.";
RL Poult. Sci. 80:284-288(2001).
CC -!- FUNCTION: Transcription factor that binds specifically to the RAS-
CC responsive elements (RRE) of gene promoters. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Broadly expressed, except in brain.
CC {ECO:0000269|PubMed:9427563}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF013754; AAB96584.1; -; mRNA.
DR EMBL; AF221559; AAF71241.1; -; mRNA.
DR EMBL; AF221560; AAF71242.1; -; mRNA.
DR PIR; JC6510; JC6510.
DR RefSeq; NP_990380.1; NM_205049.1.
DR AlphaFoldDB; O57415; -.
DR STRING; 9031.ENSGALP00000036443; -.
DR PaxDb; O57415; -.
DR PRIDE; O57415; -.
DR GeneID; 395920; -.
DR KEGG; gga:395920; -.
DR CTD; 6239; -.
DR VEuPathDB; HostDB:geneid_395920; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; O57415; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; O57415; -.
DR PRO; PR:O57415; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1615
FT /note="Ras-responsive element-binding protein 1"
FT /id="PRO_0000295156"
FT ZN_FING 47..69
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 78..100
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 106..128
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 189..211
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 216..239
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 297..319
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 622..644
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 650..672
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 732..754
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 763..788
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1170..1192
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1298..1320
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1419..1441
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1447..1469
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1313..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1043
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1245..1259
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 837
FT /note="L -> S (in strain: Leghorn)"
FT /evidence="ECO:0000269|PubMed:11261557"
FT VARIANT 932
FT /note="W -> C (in strain: Leghorn)"
FT /evidence="ECO:0000269|PubMed:11261557"
SQ SEQUENCE 1615 AA; 178389 MW; 4D22E8480E55874B CRC64;
MMSAVMNVGK IAENGGTSQT VKSPSKSPAP NRIGRRNQET KEEKSSYTCP LCEKICTTQH
QLTMHIRQHN TDTGGTDHSC SICGKSLSSA SSLDRHMLVH SGERPYKCSV CGQSFTTNGN
MHRHMKIHEK DPNSTASTTP PSPLKAKRLS SKRKFSQDAE MDREERTPAK KVVEDGQYGE
GDRKEDDAYH CPVCFKDFFC KYALESHMET HPDNSLRCDI CCITFRTHRG LLRHNAVIHK
QLPRDPTGKP FIQNNPSIPA GFHDLGFTDF SCRKFPRISQ VWCETNLRRC ISEFHRFICE
TCNKAFPMLL ALKLHTETHV MDQGRDKHKL QSTSLPSENP DQKAFMASLG LQYTKDIKPV
KQEDDTQDEV QEMRLRALKS NLPQEPGSTG LLSLSPLEAA TMGGPFSVLP PTKENIKLLS
LQPFQKGFII QPDSSIVVKP ISNESAIELA DIQQILKMAS SAPPQISLPP LSKAPSVPVQ
SIFKHMPPLK PKPLVTPRTV VATSTPPPLI SAQQASPGCI SPSLPPPPLR LIKNSVETSS
NSHLSQPGAK SSPSSQLLLQ PKVEPLTQHE MKTQLEQDSI IEALLPLNME AKIKQEVTEG
DLKAIIAGAA NKKAPTMRKV LYPCRFCDQV FAFSGVLRAH IRSHLGISPY QCNICDYIAA
DKAALIRHLR THSGERPYIC KICHYPGTVK ANCERHLRKK HLKVTRKDIE KNIEYVTSNA
AEMVDAFCSP DTVCKLCGED LKHYRALRIH MRTHSGCQKK KPFECKECGT AFSAKRNCIH
HILKQHLHVQ EREIENYILV VDCSAQESHT DAPLLEDSTY MDCKPITPFL EPQNGFLLGT
SSHVPIKLEP MGNFPMDFDE PLDFSQKSKN LSAVQVKQEN LLVSSPLSFY DCSMEPIDLS
IPKVLKRDND IPGEARNQEL ASSVITDNAY NWQQCPLGFG ANGNSEKNRA VGHPQPLKGS
LHLTVPIISP ALLGNSALLR PLRPKPPPQP LLPKPPVTKE LPPLASIAQI ISSVSSAPAL
LKTEAADASP KAASSSTGCD KSGNAKAKMT IVTAIQRDSN LPSDLTQACD PEPSPIADTG
LTKKRGRKKG TKNKPKLSSG VDLESSGEFA SIEKMLATTD TNKFSPFLQS TDNFKEESGQ
NGTSEDEKET PEDKLLRGKR NTYSDCPQKI TCPYCPRVFS WASSLQRHML THTDSQADTE
APATGGEVLD LTSCEKEQPE EVSELPGSEC SPQEEQKADS PPAEEDAEEK ADEYEEGPEE
DSVSNKSLDL NFASKLMDFK LAESDQSAGS SSQTERKHAC DVCGKTFKFA GALSRHKKAH
IREDRKDERS SEDESKSIQD DAGAPSMQDS GLEQEESPMD LKVVESPLDC EATGKENEES
ESISEGEGTE RKSTEKSSDD KIPKTDEAKS TAKADKRKKV CTVCNKRFWS LQDLTRHMRS
HTGERPYKCQ TCERTFTLKH SLVRHQRIHQ KVKNTRNHGK ESDKEETQSR CGEDSENESS
HSGTNPISEN ECDFAGVVGS HPSGTRSRKE SLVGAAKDVP CEEERPSGQG ATADLVEPAK
STQKQPAKDQ EPRGSSELER PSGFIQDLLE MHNKKSPMNH ILASADSTPQ LLGVE
