AVPI1_HUMAN
ID AVPI1_HUMAN Reviewed; 147 AA.
AC Q5T686; Q53G32; Q9H2R9; Q9HBN9;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Arginine vasopressin-induced protein 1;
DE Short=AVP-induced protein 1;
GN Name=AVPI1; ORFNames=NPD013, PP5395;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-41.
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RA Cheng Z., Gao G., Peng Y., Ren S., Chen Z., Han Z.;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-41.
RC TISSUE=Adipose tissue;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-41.
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in MAP kinase activation, epithelial sodium
CC channel (ENaC) down-regulation and cell cycling. {ECO:0000250}.
CC -!- INTERACTION:
CC Q5T686; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-8640233, EBI-8643161;
CC Q5T686; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-8640233, EBI-12011224;
CC Q5T686; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-8640233, EBI-5278764;
CC Q5T686; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-8640233, EBI-3867333;
CC Q5T686; Q9BY27: DGCR6L; NbExp=3; IntAct=EBI-8640233, EBI-742953;
CC Q5T686; P50402: EMD; NbExp=3; IntAct=EBI-8640233, EBI-489887;
CC Q5T686; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-8640233, EBI-744099;
CC Q5T686; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-8640233, EBI-5916454;
CC Q5T686; Q15323: KRT31; NbExp=3; IntAct=EBI-8640233, EBI-948001;
CC Q5T686; Q6A162: KRT40; NbExp=3; IntAct=EBI-8640233, EBI-10171697;
CC Q5T686; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-8640233, EBI-12012928;
CC Q5T686; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-8640233, EBI-10172290;
CC Q5T686; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-8640233, EBI-10171774;
CC Q5T686; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-8640233, EBI-10172052;
CC Q5T686; P59991: KRTAP12-2; NbExp=4; IntAct=EBI-8640233, EBI-10176379;
CC Q5T686; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-8640233, EBI-10172511;
CC Q5T686; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-8640233, EBI-11742507;
CC Q5T686; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-8640233, EBI-2341787;
CC Q5T686; Q99750: MDFI; NbExp=7; IntAct=EBI-8640233, EBI-724076;
CC Q5T686; Q13064: MKRN3; NbExp=3; IntAct=EBI-8640233, EBI-2340269;
CC Q5T686; O43189: PHF1; NbExp=3; IntAct=EBI-8640233, EBI-530034;
CC Q5T686; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-8640233, EBI-79165;
CC Q5T686; O15160: POLR1C; NbExp=3; IntAct=EBI-8640233, EBI-1055079;
CC Q5T686; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-8640233, EBI-710402;
CC Q5T686; P54646: PRKAA2; NbExp=3; IntAct=EBI-8640233, EBI-1383852;
CC Q5T686; P17612: PRKACA; NbExp=3; IntAct=EBI-8640233, EBI-476586;
CC Q5T686; P22694: PRKACB; NbExp=3; IntAct=EBI-8640233, EBI-2679622;
CC Q5T686; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-8640233, EBI-10226430;
CC Q5T686; Q5TAB7: RIPPLY2; NbExp=3; IntAct=EBI-8640233, EBI-10246897;
CC Q5T686; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-8640233, EBI-748391;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG44474.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF218019; AAG17261.1; -; mRNA.
DR EMBL; AF241786; AAG44474.1; ALT_FRAME; mRNA.
DR EMBL; AK223099; BAD96819.1; -; mRNA.
DR EMBL; AK222493; BAD96213.1; -; mRNA.
DR EMBL; AL355315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC000877; AAH00877.1; -; mRNA.
DR CCDS; CCDS7470.1; -.
DR RefSeq; NP_068378.2; NM_021732.2.
DR RefSeq; XP_016871983.1; XM_017016494.1.
DR AlphaFoldDB; Q5T686; -.
DR BioGRID; 121901; 47.
DR IntAct; Q5T686; 31.
DR MINT; Q5T686; -.
DR STRING; 9606.ENSP00000359660; -.
DR iPTMnet; Q5T686; -.
DR PhosphoSitePlus; Q5T686; -.
DR BioMuta; AVPI1; -.
DR DMDM; 317373474; -.
DR EPD; Q5T686; -.
DR MassIVE; Q5T686; -.
DR MaxQB; Q5T686; -.
DR PaxDb; Q5T686; -.
DR PeptideAtlas; Q5T686; -.
DR PRIDE; Q5T686; -.
DR Antibodypedia; 52147; 174 antibodies from 19 providers.
DR DNASU; 60370; -.
DR Ensembl; ENST00000370626.4; ENSP00000359660.3; ENSG00000119986.7.
DR GeneID; 60370; -.
DR KEGG; hsa:60370; -.
DR MANE-Select; ENST00000370626.4; ENSP00000359660.3; NM_021732.3; NP_068378.2.
DR UCSC; uc057vge.1; human.
DR CTD; 60370; -.
DR DisGeNET; 60370; -.
DR GeneCards; AVPI1; -.
DR HGNC; HGNC:30898; AVPI1.
DR HPA; ENSG00000119986; Low tissue specificity.
DR MIM; 618537; gene.
DR neXtProt; NX_Q5T686; -.
DR OpenTargets; ENSG00000119986; -.
DR PharmGKB; PA134905326; -.
DR VEuPathDB; HostDB:ENSG00000119986; -.
DR eggNOG; ENOG502SBE0; Eukaryota.
DR GeneTree; ENSGT00510000049872; -.
DR HOGENOM; CLU_106134_0_0_1; -.
DR InParanoid; Q5T686; -.
DR OMA; NWKKPGP; -.
DR OrthoDB; 1572792at2759; -.
DR PhylomeDB; Q5T686; -.
DR TreeFam; TF338287; -.
DR PathwayCommons; Q5T686; -.
DR SignaLink; Q5T686; -.
DR BioGRID-ORCS; 60370; 14 hits in 1088 CRISPR screens.
DR ChiTaRS; AVPI1; human.
DR GeneWiki; AVPI1; -.
DR GenomeRNAi; 60370; -.
DR Pharos; Q5T686; Tdark.
DR PRO; PR:Q5T686; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5T686; protein.
DR Bgee; ENSG00000119986; Expressed in mucosa of stomach and 184 other tissues.
DR Genevisible; Q5T686; HS.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR InterPro; IPR039579; AVPI1.
DR InterPro; IPR020282; Avpi1/C8orf4_dom.
DR PANTHER; PTHR14350; PTHR14350; 1.
DR Pfam; PF15063; TC1; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Reference proteome.
FT CHAIN 1..147
FT /note="Arginine vasopressin-induced protein 1"
FT /id="PRO_0000282402"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 41
FT /note="A -> G (in dbSNP:rs2275047)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:15498874, ECO:0000269|Ref.3"
FT /id="VAR_031405"
FT CONFLICT 65
FT /note="H -> R (in Ref. 2; AAG44474)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="R -> K (in Ref. 3; BAD96819)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 147 AA; 16773 MW; E01AEFEEF3F9006B CRC64;
MGTPASVVSE PPPWQAPIEA RGRKQASANI FQDAELLQIQ ALFQRSGDQL AEERAQIIWE
CAGDHRVAEA LKRLRRKRPP RQKPLGHSLH HCSRLRILEP HSALANPQSA TETASSEQYL
HSRKKSARIR RNWRKSGPTS YLHQIRH
