AVPI1_MOUSE
ID AVPI1_MOUSE Reviewed; 142 AA.
AC Q9D7H4;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Arginine vasopressin-induced protein 1;
DE Short=AVP-induced protein 1;
DE AltName: Full=Arginine vasopressin-induced transcript 32 protein;
DE Short=VIP32;
DE Short=VIT32;
GN Name=Avpi1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RX PubMed=12356727; DOI=10.1093/emboj/cdf509;
RA Nicod M., Michlig S., Flahaut M., Salinas M., Fowler-Jaeger N.,
RA Horisberger J.-D., Rossier B.C., Firsov D.;
RT "A novel vasopressin-induced transcript promotes MAP kinase activation and
RT ENaC downregulation.";
RL EMBO J. 21:5109-5117(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INDUCTION.
RX PubMed=15140762; DOI=10.1152/ajprenal.00107.2004;
RA Thomas C.P., Loftus R.W., Liu K.Z.;
RT "AVP-induced VIT32 gene expression in collecting duct cells occurs via
RT trans-activation of a CRE in the 5'-flanking region of the VIT32 gene.";
RL Am. J. Physiol. 287:F460-F468(2004).
CC -!- FUNCTION: May be involved in MAP kinase activation, epithelial sodium
CC channel (ENaC) down-regulation and cell cycling.
CC {ECO:0000269|PubMed:12356727}.
CC -!- INDUCTION: By vasopressin. {ECO:0000269|PubMed:12356727,
CC ECO:0000269|PubMed:15140762}.
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DR EMBL; AK009243; BAB26163.1; -; mRNA.
DR EMBL; BC027646; AAH27646.1; -; mRNA.
DR CCDS; CCDS29822.1; -.
DR RefSeq; NP_081382.1; NM_027106.4.
DR AlphaFoldDB; Q9D7H4; -.
DR SMR; Q9D7H4; -.
DR STRING; 10090.ENSMUSP00000018965; -.
DR PhosphoSitePlus; Q9D7H4; -.
DR MaxQB; Q9D7H4; -.
DR PaxDb; Q9D7H4; -.
DR PRIDE; Q9D7H4; -.
DR ProteomicsDB; 273432; -.
DR Antibodypedia; 52147; 174 antibodies from 19 providers.
DR DNASU; 69534; -.
DR Ensembl; ENSMUST00000018965; ENSMUSP00000018965; ENSMUSG00000018821.
DR GeneID; 69534; -.
DR KEGG; mmu:69534; -.
DR UCSC; uc008hnh.1; mouse.
DR CTD; 60370; -.
DR MGI; MGI:1916784; Avpi1.
DR VEuPathDB; HostDB:ENSMUSG00000018821; -.
DR eggNOG; ENOG502SBE0; Eukaryota.
DR GeneTree; ENSGT00510000049872; -.
DR HOGENOM; CLU_106134_0_0_1; -.
DR InParanoid; Q9D7H4; -.
DR OMA; NWKKPGP; -.
DR OrthoDB; 1572792at2759; -.
DR PhylomeDB; Q9D7H4; -.
DR TreeFam; TF338287; -.
DR BioGRID-ORCS; 69534; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9D7H4; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9D7H4; protein.
DR Bgee; ENSMUSG00000018821; Expressed in lip and 234 other tissues.
DR ExpressionAtlas; Q9D7H4; baseline and differential.
DR Genevisible; Q9D7H4; MM.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.
DR InterPro; IPR039579; AVPI1.
DR InterPro; IPR020282; Avpi1/C8orf4_dom.
DR PANTHER; PTHR14350; PTHR14350; 1.
DR Pfam; PF15063; TC1; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Reference proteome.
FT CHAIN 1..142
FT /note="Arginine vasopressin-induced protein 1"
FT /id="PRO_0000282403"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 142 AA; 15802 MW; 4C5B8CED9D7803BB CRC64;
MGTPASVVSE PPLWQVSTPQ TRGRKQASAN IFQDAELVQI QGLFQRSGDQ LAEERAQIIW
ECAGDHRVAE ALRRLRRKRP PKQNHCSRLR VPEPGSTASD PQASTTDTAS SEQSGNSRRT
SARAPRNWNK PGPTGYLHQI RH
