AB8G_ARATH
ID AB8G_ARATH Reviewed; 589 AA.
AC Q9FLX5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=ABC transporter G family member 8;
DE Short=ABC transporter ABCG.8;
DE Short=AtABCG8;
DE AltName: Full=Probable white-brown complex homolog protein 8;
DE Short=AtWBC8;
GN Name=ABCG8; Synonyms=WBC8; OrderedLocusNames=At5g52860; ORFNames=MXC20.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR EMBL; AB009055; BAB10434.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96269.1; -; Genomic_DNA.
DR RefSeq; NP_200098.1; NM_124664.3.
DR AlphaFoldDB; Q9FLX5; -.
DR SMR; Q9FLX5; -.
DR BioGRID; 20608; 2.
DR IntAct; Q9FLX5; 1.
DR STRING; 3702.AT5G52860.1; -.
DR PaxDb; Q9FLX5; -.
DR PRIDE; Q9FLX5; -.
DR ProteomicsDB; 244369; -.
DR EnsemblPlants; AT5G52860.1; AT5G52860.1; AT5G52860.
DR GeneID; 835363; -.
DR Gramene; AT5G52860.1; AT5G52860.1; AT5G52860.
DR KEGG; ath:AT5G52860; -.
DR Araport; AT5G52860; -.
DR TAIR; locus:2176937; AT5G52860.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; Q9FLX5; -.
DR OMA; QAKICVV; -.
DR OrthoDB; 1022017at2759; -.
DR PhylomeDB; Q9FLX5; -.
DR PRO; PR:Q9FLX5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FLX5; baseline and differential.
DR Genevisible; Q9FLX5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..589
FT /note="ABC transporter G family member 8"
FT /id="PRO_0000240680"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 16..261
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 311..521
FT /note="ABC transmembrane type-2"
FT BINDING 62..69
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 589 AA; 65934 MW; 4E1D1605B552FDC4 CRC64;
MEIPPSPPPE TAAYTLTTSS ISYTIPKTSL SLLRFPATEP PSFILRNITL TAHPTEILAV
VGPSGAGKST LLDILASKTS PTSGSILLNS IPINPSSYRK ISSYVPQHDS FFPLLTVSET
FSFAACLLLP NPSIVSETVT SLLSELNLTH LSHTRLAQGL SGGERRRVSI GLSLLHDPCF
LLLDEPTSGL DSKSAFDVIH ILKSIAVSRQ RTVILSIHQP SFKILSIIDR LLLLSKGTVV
YHGRLDSLEG FLLFKGFTVP PQLNSLEYAM EILQELRESD GNTDATALPS IENRKQREKQ
SIVRYRKSRI TEISLLARRF WKIIYRTRQL LLTNALEALV VGLVLGTIYI NIGIGKAGIE
KRFGMFAFTL TFLLSSTTET LPIFINERPI LLRETSSGIY RLSSHILANT LVFLPYLFVI
SIIYSVSVYF LIGLCPTWQA FGYFVLVIWI ILLMANSFVL FLSSLAPNYI TGTSLVTILL
AAFFLFSGYF ISKESLPKYW LFMYFFSMYK YALDALLINE YSCLASKCLV WLEEAQTKIC
MVTGGDVLKK KGLHEKQRWF NVYVLLGFFV LYRVLCFLAL LRRVSGSKR
