RRF_MYCTA
ID RRF_MYCTA Reviewed; 185 AA.
AC A5U6N7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Ribosome-recycling factor {ECO:0000255|HAMAP-Rule:MF_00040};
DE Short=RRF {ECO:0000255|HAMAP-Rule:MF_00040};
DE AltName: Full=Ribosome-releasing factor {ECO:0000255|HAMAP-Rule:MF_00040};
GN Name=frr {ECO:0000255|HAMAP-Rule:MF_00040}; OrderedLocusNames=MRA_2907;
OS Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=419947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25177 / H37Ra;
RX PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA Wang H., Wang S., Zhao G., Zhang Y.;
RT "Genetic basis of virulence attenuation revealed by comparative genomic
RT analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL PLoS ONE 3:E2375-E2375(2008).
CC -!- FUNCTION: Responsible for the release of ribosomes from messenger RNA
CC at the termination of protein biosynthesis. May increase the efficiency
CC of translation by recycling ribosomes from one round of translation to
CC another. {ECO:0000255|HAMAP-Rule:MF_00040}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00040}.
CC -!- SIMILARITY: Belongs to the RRF family. {ECO:0000255|HAMAP-
CC Rule:MF_00040}.
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DR EMBL; CP000611; ABQ74687.1; -; Genomic_DNA.
DR RefSeq; WP_003414663.1; NZ_CP016972.1.
DR AlphaFoldDB; A5U6N7; -.
DR SMR; A5U6N7; -.
DR STRING; 419947.MRA_2907; -.
DR EnsemblBacteria; ABQ74687; ABQ74687; MRA_2907.
DR GeneID; 45426870; -.
DR KEGG; mra:MRA_2907; -.
DR eggNOG; COG0233; Bacteria.
DR HOGENOM; CLU_073981_2_0_11; -.
DR OMA; FNPMNNG; -.
DR OrthoDB; 1674344at2; -.
DR Proteomes; UP000001988; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006415; P:translational termination; IEA:UniProtKB-UniRule.
DR CDD; cd00520; RRF; 1.
DR Gene3D; 1.10.132.20; -; 1.
DR HAMAP; MF_00040; RRF; 1.
DR InterPro; IPR002661; Ribosome_recyc_fac.
DR InterPro; IPR023584; Ribosome_recyc_fac_dom.
DR InterPro; IPR036191; RRF_sf.
DR PANTHER; PTHR20982; PTHR20982; 1.
DR Pfam; PF01765; RRF; 1.
DR SUPFAM; SSF55194; SSF55194; 1.
DR TIGRFAMs; TIGR00496; frr; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Protein biosynthesis.
FT CHAIN 1..185
FT /note="Ribosome-recycling factor"
FT /id="PRO_1000003205"
FT REGION 144..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 185 AA; 20828 MW; 8C711A42089F5CA2 CRC64;
MIDEALFDAE EKMEKAVAVA RDDLSTIRTG RANPGMFSRI TIDYYGAATP ITQLASINVP
EARLVVIKPY EANQLRAIET AIRNSDLGVN PTNDGALIRV AVPQLTEERR RELVKQAKHK
GEEAKVSVRN IRRKAMEELH RIRKEGEAGE DEVGRAEKDL DKTTHQYVTQ IDELVKHKEG
ELLEV