RRF_MYCTU
ID RRF_MYCTU Reviewed; 185 AA.
AC P9WGY1; L0TCI6; P66734; Q10794;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Ribosome-recycling factor {ECO:0000255|HAMAP-Rule:MF_00040};
DE Short=RRF {ECO:0000255|HAMAP-Rule:MF_00040};
DE AltName: Full=Ribosome-releasing factor {ECO:0000255|HAMAP-Rule:MF_00040};
GN Name=frr {ECO:0000255|HAMAP-Rule:MF_00040}; OrderedLocusNames=Rv2882c;
GN ORFNames=MTCY274.13c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Responsible for the release of ribosomes from messenger RNA
CC at the termination of protein biosynthesis. May increase the efficiency
CC of translation by recycling ribosomes from one round of translation to
CC another. {ECO:0000255|HAMAP-Rule:MF_00040}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00040}.
CC -!- SIMILARITY: Belongs to the RRF family. {ECO:0000255|HAMAP-
CC Rule:MF_00040}.
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DR EMBL; AL123456; CCP45684.1; -; Genomic_DNA.
DR PIR; E70924; E70924.
DR RefSeq; NP_217398.1; NC_000962.3.
DR RefSeq; WP_003414663.1; NZ_NVQJ01000006.1.
DR PDB; 1WQF; X-ray; 2.65 A; A=1-185.
DR PDB; 1WQG; X-ray; 2.15 A; A=1-185.
DR PDB; 1WQH; X-ray; 2.90 A; A=1-185.
DR PDB; 4KAW; X-ray; 2.50 A; X=1-185.
DR PDB; 4KB2; X-ray; 2.30 A; A=1-185.
DR PDB; 4KB4; X-ray; 2.25 A; A=1-185.
DR PDB; 4KC6; X-ray; 2.40 A; A=1-179.
DR PDB; 4KDD; X-ray; 1.90 A; A=1-185.
DR PDBsum; 1WQF; -.
DR PDBsum; 1WQG; -.
DR PDBsum; 1WQH; -.
DR PDBsum; 4KAW; -.
DR PDBsum; 4KB2; -.
DR PDBsum; 4KB4; -.
DR PDBsum; 4KC6; -.
DR PDBsum; 4KDD; -.
DR AlphaFoldDB; P9WGY1; -.
DR SMR; P9WGY1; -.
DR STRING; 83332.Rv2882c; -.
DR PaxDb; P9WGY1; -.
DR DNASU; 887464; -.
DR GeneID; 45426870; -.
DR GeneID; 887464; -.
DR KEGG; mtu:Rv2882c; -.
DR TubercuList; Rv2882c; -.
DR eggNOG; COG0233; Bacteria.
DR OMA; FNPMNNG; -.
DR PhylomeDB; P9WGY1; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR GO; GO:0008079; F:translation termination factor activity; IDA:MTBBASE.
DR GO; GO:0002184; P:cytoplasmic translational termination; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR GO; GO:0006415; P:translational termination; IDA:MTBBASE.
DR CDD; cd00520; RRF; 1.
DR Gene3D; 1.10.132.20; -; 1.
DR HAMAP; MF_00040; RRF; 1.
DR InterPro; IPR002661; Ribosome_recyc_fac.
DR InterPro; IPR023584; Ribosome_recyc_fac_dom.
DR InterPro; IPR036191; RRF_sf.
DR PANTHER; PTHR20982; PTHR20982; 1.
DR Pfam; PF01765; RRF; 1.
DR SUPFAM; SSF55194; SSF55194; 1.
DR TIGRFAMs; TIGR00496; frr; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Protein biosynthesis; Reference proteome.
FT CHAIN 1..185
FT /note="Ribosome-recycling factor"
FT /id="PRO_0000167500"
FT REGION 144..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 2..24
FT /evidence="ECO:0007829|PDB:4KDD"
FT STRAND 29..31
FT /evidence="ECO:0007829|PDB:4KB4"
FT HELIX 34..37
FT /evidence="ECO:0007829|PDB:4KDD"
FT STRAND 41..43
FT /evidence="ECO:0007829|PDB:4KDD"
FT STRAND 45..50
FT /evidence="ECO:0007829|PDB:4KDD"
FT HELIX 51..53
FT /evidence="ECO:0007829|PDB:4KDD"
FT STRAND 54..61
FT /evidence="ECO:0007829|PDB:4KDD"
FT STRAND 64..71
FT /evidence="ECO:0007829|PDB:4KDD"
FT HELIX 72..74
FT /evidence="ECO:0007829|PDB:4KDD"
FT HELIX 75..84
FT /evidence="ECO:0007829|PDB:4KDD"
FT STRAND 85..87
FT /evidence="ECO:0007829|PDB:4KB2"
FT STRAND 92..96
FT /evidence="ECO:0007829|PDB:4KB4"
FT STRAND 98..101
FT /evidence="ECO:0007829|PDB:4KDD"
FT HELIX 107..144
FT /evidence="ECO:0007829|PDB:4KDD"
FT HELIX 150..182
FT /evidence="ECO:0007829|PDB:4KDD"
SQ SEQUENCE 185 AA; 20828 MW; 8C711A42089F5CA2 CRC64;
MIDEALFDAE EKMEKAVAVA RDDLSTIRTG RANPGMFSRI TIDYYGAATP ITQLASINVP
EARLVVIKPY EANQLRAIET AIRNSDLGVN PTNDGALIRV AVPQLTEERR RELVKQAKHK
GEEAKVSVRN IRRKAMEELH RIRKEGEAGE DEVGRAEKDL DKTTHQYVTQ IDELVKHKEG
ELLEV
