AVT1C_ARATH
ID AVT1C_ARATH Reviewed; 550 AA.
AC F4IUW3; Q8S8P2; Q949Y8; Q9ZUZ5;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Amino acid transporter AVT1C {ECO:0000305};
DE Short=AtAvt1C {ECO:0000303|PubMed:27925655};
GN Name=AVT1C {ECO:0000303|PubMed:27925655};
GN OrderedLocusNames=At2g39130 {ECO:0000312|Araport:AT2G39130};
GN ORFNames=T16B24.23 {ECO:0000312|EMBL:AAM14997.1},
GN T7F6.1 {ECO:0000312|EMBL:AAC79623.3};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27925655; DOI=10.1002/1873-3468.12507;
RA Fujiki Y., Teshima H., Kashiwao S., Kawano-Kawada M., Ohsumi Y.,
RA Kakinuma Y., Sekito T.;
RT "Functional identification of AtAVT3, a family of vacuolar amino acid
RT transporters, in Arabidopsis.";
RL FEBS Lett. 591:5-15(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.5) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC79623.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM14997.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004697; AAM14997.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC005770; AAC79623.3; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09638.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM62501.1; -; Genomic_DNA.
DR EMBL; AY050801; AAK92736.1; -; mRNA.
DR PIR; E84813; E84813.
DR PIR; T02589; T02589.
DR RefSeq; NP_001324655.1; NM_001336758.1.
DR RefSeq; NP_850312.1; NM_179981.3.
DR AlphaFoldDB; F4IUW3; -.
DR SMR; F4IUW3; -.
DR IntAct; F4IUW3; 2.
DR STRING; 3702.AT2G39130.1; -.
DR iPTMnet; F4IUW3; -.
DR PaxDb; F4IUW3; -.
DR PRIDE; F4IUW3; -.
DR EnsemblPlants; AT2G39130.1; AT2G39130.1; AT2G39130.
DR EnsemblPlants; AT2G39130.2; AT2G39130.2; AT2G39130.
DR GeneID; 818499; -.
DR Gramene; AT2G39130.1; AT2G39130.1; AT2G39130.
DR Gramene; AT2G39130.2; AT2G39130.2; AT2G39130.
DR KEGG; ath:AT2G39130; -.
DR Araport; AT2G39130; -.
DR TAIR; locus:2056118; AT2G39130.
DR eggNOG; KOG1303; Eukaryota.
DR HOGENOM; CLU_009646_1_0_1; -.
DR InParanoid; F4IUW3; -.
DR OMA; KTFFQDG; -.
DR OrthoDB; 570025at2759; -.
DR PRO; PR:F4IUW3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IUW3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..550
FT /note="Amino acid transporter AVT1C"
FT /id="PRO_0000440104"
FT TRANSMEM 165..185
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..484
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..510
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 259
FT /note="S -> I (in Ref. 3; AAK92736)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 550 AA; 60070 MW; F79A94AE7DEFD0D7 CRC64;
MNHVPSDQSF YIESEDEDDR KDYVEEDGGS HSDSSDDVYD ENQAHIKPSS YTTAWPQSYR
QSIDLYSSVP SPGIGFLGNN SMTRFGSSFL SSGLIRRHTP ESLPTVTKPL LEEQADEQAL
PKHRLSSQGL LSPIPSRRGS MRKDEKSSMV SHEIPMSRNS SYGQAVLNGL NVLCGVGILS
TPYAAKEGGW LGLMILFVYG LLSFYTGILL RYCLDSESDL ETYPDIGQAA FGTTGRIFVS
IVLYLELYAC CVEYIILESD NLSSLYPNAA LSIGGFQLDA RHLFALLTTL AVLPTVWLRD
LSVLSYISAG GVIASVLVVL CLFWIGLVDE VGIHSKGTTL NLSTLPVAIG LYGYCYSGHA
VFPNIYTSMA KPSQYPAVLL TCFGICTLMY AGVAVMGYTM FGESTQSQFT LNLPQDLIAT
KIAVWTTVVN PFTKYALTIS PVAMSLEELI PSRHIRSHWY AIGIRTLLVF STLLVGLAIP
FFGLVMSLIG SLLTMLVTLI LPPACFLSIV RRKVTPTQMM LCVLIIIVGA ISSVIGSYSA
LSKIVEKLTN
