AVT1D_ARATH
ID AVT1D_ARATH Reviewed; 550 AA.
AC Q8GYS4; Q9LZL4;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Amino acid transporter AVT1D {ECO:0000305};
DE Short=AtAvt1D {ECO:0000303|PubMed:27925655};
GN Name=AVT1D {ECO:0000303|PubMed:27925655};
GN OrderedLocusNames=At5g02180 {ECO:0000312|Araport:AT5G02180};
GN ORFNames=T7H20.230 {ECO:0000312|EMBL:CAB82991.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27925655; DOI=10.1002/1873-3468.12507;
RA Fujiki Y., Teshima H., Kashiwao S., Kawano-Kawada M., Ohsumi Y.,
RA Kakinuma Y., Sekito T.;
RT "Functional identification of AtAVT3, a family of vacuolar amino acid
RT transporters, in Arabidopsis.";
RL FEBS Lett. 591:5-15(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.5) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB82991.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL162508; CAB82991.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED90441.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69615.1; -; Genomic_DNA.
DR EMBL; AK117421; BAC42086.1; -; mRNA.
DR PIR; T48239; T48239.
DR RefSeq; NP_001331278.1; NM_001342649.1.
DR RefSeq; NP_195838.2; NM_120296.5.
DR AlphaFoldDB; Q8GYS4; -.
DR SMR; Q8GYS4; -.
DR STRING; 3702.AT5G02180.1; -.
DR iPTMnet; Q8GYS4; -.
DR PaxDb; Q8GYS4; -.
DR PRIDE; Q8GYS4; -.
DR ProteomicsDB; 240937; -.
DR EnsemblPlants; AT5G02180.1; AT5G02180.1; AT5G02180.
DR EnsemblPlants; AT5G02180.2; AT5G02180.2; AT5G02180.
DR GeneID; 831862; -.
DR Gramene; AT5G02180.1; AT5G02180.1; AT5G02180.
DR Gramene; AT5G02180.2; AT5G02180.2; AT5G02180.
DR KEGG; ath:AT5G02180; -.
DR Araport; AT5G02180; -.
DR TAIR; locus:2185158; AT5G02180.
DR eggNOG; KOG1303; Eukaryota.
DR HOGENOM; CLU_009646_1_0_1; -.
DR InParanoid; Q8GYS4; -.
DR OMA; VFCFIVV; -.
DR OrthoDB; 570025at2759; -.
DR PhylomeDB; Q8GYS4; -.
DR PRO; PR:Q8GYS4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8GYS4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..550
FT /note="Amino acid transporter AVT1D"
FT /id="PRO_0000440105"
FT TRANSMEM 164..184
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..286
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 521..541
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 59667 MW; 0C4601B592099DD6 CRC64;
MKLDEEFLHD RDHSFLTDDE ENQAALACSD DEHDGDDDGR RGGENSDSSS PLSRDRSDNN
LSDVSNPPWP QSYRQSMDLL TGMTPPSVSF MPQSSSRRLA SSFQKKQQSS FCDSLSSSSS
KPLLSQPVPD KEETILPVNP QSQLKLSVTD LPLPEPNLCS FSQSVLNGTN VLCGLGLITM
PYAIKESGWL GLPILLFFGV ITCYTGVLMK RCLESSPGIQ TYPDIGQAAF GITGRFIISI
LLYVELYAAC VEYIIMMSDN LSGLFPNVSL SIASGISLDS PQIFAILTTL LVLPTVWLKD
LSLLSYLSVG GVLASILLGI CLFWVGAVDG IGFHATGRVF DLSNLPVTIG IFGFGYSGHS
VFPNIYSSMK DPSRFPLVLV ICFSFCTVLY IAVAVCGYTM FGEAVESQFT LNMPKHFFPS
KVAVWTAVIT PMTKYALTIT PIVMSLEELI PTAKMRSRGV SILFRTMLVT STLVVALSVP
FFAIVAALIG SFLAMLVALI FPCLCYLSIL KGKLSNTQIG LCIFIIVFGV VSGCCGTYSA
ISRLANQMTD
