AVT1E_ARATH
ID AVT1E_ARATH Reviewed; 526 AA.
AC Q8LPF4; Q9LZL5;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Amino acid transporter AVT1E {ECO:0000305};
DE Short=AtAvt1E {ECO:0000303|PubMed:27925655};
GN Name=AVT1E {ECO:0000303|PubMed:27925655};
GN OrderedLocusNames=At5g02170 {ECO:0000312|Araport:AT5G02170};
GN ORFNames=T7H20.220 {ECO:0000312|EMBL:CAB82990.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27925655; DOI=10.1002/1873-3468.12507;
RA Fujiki Y., Teshima H., Kashiwao S., Kawano-Kawada M., Ohsumi Y.,
RA Kakinuma Y., Sekito T.;
RT "Functional identification of AtAVT3, a family of vacuolar amino acid
RT transporters, in Arabidopsis.";
RL FEBS Lett. 591:5-15(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=Additional isoforms seem to exist. {ECO:0000305};
CC Name=1;
CC IsoId=Q8LPF4-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.5) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB82990.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL162508; CAB82990.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED90439.1; -; Genomic_DNA.
DR EMBL; AY102114; AAM26683.1; -; mRNA.
DR EMBL; BT005813; AAO64748.1; -; mRNA.
DR PIR; T48238; T48238.
DR RefSeq; NP_195837.2; NM_120295.4. [Q8LPF4-1]
DR AlphaFoldDB; Q8LPF4; -.
DR SMR; Q8LPF4; -.
DR IntAct; Q8LPF4; 1.
DR STRING; 3702.AT5G02170.1; -.
DR iPTMnet; Q8LPF4; -.
DR PaxDb; Q8LPF4; -.
DR PRIDE; Q8LPF4; -.
DR ProteomicsDB; 241155; -. [Q8LPF4-1]
DR EnsemblPlants; AT5G02170.1; AT5G02170.1; AT5G02170. [Q8LPF4-1]
DR GeneID; 831896; -.
DR Gramene; AT5G02170.1; AT5G02170.1; AT5G02170. [Q8LPF4-1]
DR KEGG; ath:AT5G02170; -.
DR Araport; AT5G02170; -.
DR TAIR; locus:2185143; AT5G02170.
DR eggNOG; KOG1303; Eukaryota.
DR InParanoid; Q8LPF4; -.
DR OMA; LGIFMAP; -.
DR OrthoDB; 570025at2759; -.
DR PhylomeDB; Q8LPF4; -.
DR PRO; PR:Q8LPF4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LPF4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amino-acid transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..526
FT /note="Amino acid transporter AVT1E"
FT /id="PRO_0000440106"
FT TRANSMEM 140..160
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..478
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..514
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 57538 MW; 3B22E7A17F2C2516 CRC64;
MKQNETFDQE REDLYHTFDE EDEESQTESS VPSTPLSRNR SEDVPVPWPR SYRQSMDLLT
GVTPPTSTSF VSSFRQRRQS SVFGSFTSSP SKQQLLIDKD EIQSSVVSSI KSFLASHLQL
SVPGDLLTPQ ENRSCTFSQS VLNGINVLCG VALLTMPYAV KEGGWLGLFI LFSFGIITFY
TGILLKRCLE NSPGIHTYPD IGQAAFGTTG RILVSILLYV ELYASCVEYI IMMSDNLSRM
FPNTSLYING FSLDSTQVFA ITTTLIVLPT VWLKDLSLLS YLSAGGVISS ILLALCLFWA
GSVDGVGFHI SGQALDITNI PVAIGIYGFG FGSHSVFPNI YSSMKEPSKF PTVLLISFAF
CTLFYIAVAV CGFTMFGDAI QSQFTLNMPP HFTSSKIAVW TAVVTPMTKY ALTITPVMLS
LEELIPSSSR KMRSKGVSML FRTILVLSTL VVALTVPFFA TVAALIGSFI AMLIALIFPC
LCYISIMKGR LTNFQIGICI LIVIIGIVSG CCGTYSAIAR LIGEMT
