ID   AVT1H_ARATH             Reviewed;         426 AA.
AC   Q9LFE3;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Amino acid transporter AVT1H {ECO:0000305};
DE            Short=AtAvt1H {ECO:0000303|PubMed:27925655};
GN   Name=AVT1H {ECO:0000303|PubMed:27925655};
GN   OrderedLocusNames=At5g16740 {ECO:0000312|Araport:AT5G16740};
GN   ORFNames=F5E19.80 {ECO:0000312|EMBL:CAC01838.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=27925655; DOI=10.1002/1873-3468.12507;
RA   Fujiki Y., Teshima H., Kashiwao S., Kawano-Kawada M., Ohsumi Y.,
RA   Kakinuma Y., Sekito T.;
RT   "Functional identification of AtAVT3, a family of vacuolar amino acid
RT   transporters, in Arabidopsis.";
RL   FEBS Lett. 591:5-15(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       Amino acid/auxin permease (AAAP) (TC 2.A.18.5) subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL391147; CAC01838.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED92332.1; -; Genomic_DNA.
DR   PIR; T51506; T51506.
DR   RefSeq; NP_197176.1; NM_121680.1.
DR   AlphaFoldDB; Q9LFE3; -.
DR   SMR; Q9LFE3; -.
DR   STRING; 3702.AT5G16740.1; -.
DR   PaxDb; Q9LFE3; -.
DR   PRIDE; Q9LFE3; -.
DR   EnsemblPlants; AT5G16740.1; AT5G16740.1; AT5G16740.
DR   GeneID; 831537; -.
DR   Gramene; AT5G16740.1; AT5G16740.1; AT5G16740.
DR   KEGG; ath:AT5G16740; -.
DR   Araport; AT5G16740; -.
DR   TAIR; locus:2149045; AT5G16740.
DR   eggNOG; KOG1303; Eukaryota.
DR   HOGENOM; CLU_009646_1_1_1; -.
DR   InParanoid; Q9LFE3; -.
DR   OMA; FHCMMEW; -.
DR   OrthoDB; 570025at2759; -.
DR   PhylomeDB; Q9LFE3; -.
DR   PRO; PR:Q9LFE3; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LFE3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..426
FT                   /note="Amino acid transporter AVT1H"
FT                   /id="PRO_0000440109"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   426 AA;  45808 MW;  933603771A1FA8FD CRC64;
     MVCVACVEEN KGCECEHEKP VRELVLEAAS ENSSFLHSVI NMVGMLIGLG QLSMPYAVES
     GGWMSIFLLI SFGILTTYTS HILGKCIRRN PKSKSYSDIG YSAFGRHGRL IVCLFIYLEI
     FMALVSYTIS LHDNISAAFP ATFSNHGHFP AAKLTAVAVA IALPSLWIRD LSSISFLSSG
     GILMSAIIFG SVVYTAIFGG VIDDGKIPVL RLENIPTVSG IYLFSFGGHI VFPNLYTSMK
     DPSKFTKVSI VSFATVTALY GALAITGAKM FGPSVNSQIT LSLPKHLVVT KIALWATVLT
     PMTKYALEFA PLAIQLERSL PSTMTDRTKL VARGLMGSAL LLVILALALT VPYFGYVLSL
     TGSLVSVTIA VTLPSAFYLK ICWDGMTKFT RAANLGFVVL GCVLGVLGSF ESSKLLVKEL
     VRVHGG