RRF_THEMA
ID RRF_THEMA Reviewed; 185 AA.
AC Q9X1B9;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Ribosome-recycling factor {ECO:0000255|HAMAP-Rule:MF_00040};
DE Short=RRF {ECO:0000255|HAMAP-Rule:MF_00040};
DE AltName: Full=Ribosome-releasing factor {ECO:0000255|HAMAP-Rule:MF_00040};
GN Name=frr {ECO:0000255|HAMAP-Rule:MF_00040}; OrderedLocusNames=TM_1399;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS).
RX PubMed=10600747; DOI=10.1126/science.286.5448.2349;
RA Selmer M., Al-Karadaghi S., Hirokawa G., Kaji A., Liljas A.;
RT "Crystal structure of Thermotoga maritima ribosome recycling factor: a tRNA
RT mimic.";
RL Science 286:2349-2352(1999).
CC -!- FUNCTION: Responsible for the release of ribosomes from messenger RNA
CC at the termination of protein biosynthesis. May increase the efficiency
CC of translation by recycling ribosomes from one round of translation to
CC another. {ECO:0000255|HAMAP-Rule:MF_00040}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00040}.
CC -!- SIMILARITY: Belongs to the RRF family. {ECO:0000255|HAMAP-
CC Rule:MF_00040}.
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DR EMBL; AE000512; AAD36470.1; -; Genomic_DNA.
DR PIR; H72259; H72259.
DR RefSeq; NP_229200.1; NC_000853.1.
DR RefSeq; WP_004081616.1; NZ_CP011107.1.
DR PDB; 1DD5; X-ray; 2.55 A; A=1-185.
DR PDBsum; 1DD5; -.
DR AlphaFoldDB; Q9X1B9; -.
DR BMRB; Q9X1B9; -.
DR SMR; Q9X1B9; -.
DR STRING; 243274.THEMA_07320; -.
DR EnsemblBacteria; AAD36470; AAD36470; TM_1399.
DR KEGG; tma:TM1399; -.
DR eggNOG; COG0233; Bacteria.
DR InParanoid; Q9X1B9; -.
DR OMA; FNPMNNG; -.
DR OrthoDB; 1674344at2; -.
DR EvolutionaryTrace; Q9X1B9; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR GO; GO:0002184; P:cytoplasmic translational termination; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd00520; RRF; 1.
DR Gene3D; 1.10.132.20; -; 1.
DR HAMAP; MF_00040; RRF; 1.
DR InterPro; IPR002661; Ribosome_recyc_fac.
DR InterPro; IPR023584; Ribosome_recyc_fac_dom.
DR InterPro; IPR036191; RRF_sf.
DR PANTHER; PTHR20982; PTHR20982; 1.
DR Pfam; PF01765; RRF; 1.
DR SUPFAM; SSF55194; SSF55194; 1.
DR TIGRFAMs; TIGR00496; frr; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Protein biosynthesis; Reference proteome.
FT CHAIN 1..185
FT /note="Ribosome-recycling factor"
FT /id="PRO_0000167565"
FT HELIX 4..26
FT /evidence="ECO:0007829|PDB:1DD5"
FT HELIX 34..37
FT /evidence="ECO:0007829|PDB:1DD5"
FT STRAND 41..44
FT /evidence="ECO:0007829|PDB:1DD5"
FT STRAND 47..50
FT /evidence="ECO:0007829|PDB:1DD5"
FT HELIX 51..53
FT /evidence="ECO:0007829|PDB:1DD5"
FT STRAND 54..59
FT /evidence="ECO:0007829|PDB:1DD5"
FT STRAND 64..71
FT /evidence="ECO:0007829|PDB:1DD5"
FT HELIX 74..84
FT /evidence="ECO:0007829|PDB:1DD5"
FT STRAND 85..87
FT /evidence="ECO:0007829|PDB:1DD5"
FT STRAND 98..101
FT /evidence="ECO:0007829|PDB:1DD5"
FT HELIX 107..144
FT /evidence="ECO:0007829|PDB:1DD5"
FT HELIX 150..183
FT /evidence="ECO:0007829|PDB:1DD5"
SQ SEQUENCE 185 AA; 21513 MW; 626E349B97495852 CRC64;
MVNPFIKEAK EKMKRTLEKI EDELRKMRTG KPSPAILEEI KVDYYGVPTP VNQLATISIS
EERTLVIKPW DKSVLSLIEK AINASDLGLN PINDGNVIRL VFPSPTTEQR EKWVKKAKEI
VEEGKIAIRN IRREILKKIK EDQKEGLIPE DDAKRLENEI QKLTDEFIEK LDEVFEIKKE
EIMEF
