AVT6A_ARATH
ID AVT6A_ARATH Reviewed; 460 AA.
AC Q9LI61; B9DH87;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Amino acid transporter AVT6A {ECO:0000305};
DE Short=AtAvt6A {ECO:0000303|PubMed:27925655};
GN Name=AVT6A {ECO:0000303|PubMed:27925655};
GN OrderedLocusNames=At3g30390 {ECO:0000312|Araport:AT3G30390};
GN ORFNames=T6J22.16 {ECO:0000312|EMBL:BAB02239.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf {ECO:0000312|EMBL:BAH20104.1};
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27925655; DOI=10.1002/1873-3468.12507;
RA Fujiki Y., Teshima H., Kashiwao S., Kawano-Kawada M., Ohsumi Y.,
RA Kakinuma Y., Sekito T.;
RT "Functional identification of AtAVT3, a family of vacuolar amino acid
RT transporters, in Arabidopsis.";
RL FEBS Lett. 591:5-15(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.6) subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP001314; BAB02239.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77639.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77640.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65075.1; -; Genomic_DNA.
DR EMBL; AY052201; AAK97672.1; -; mRNA.
DR EMBL; AF428287; AAL16119.1; -; mRNA.
DR EMBL; AK317437; BAH20104.1; -; mRNA.
DR RefSeq; NP_001030795.1; NM_001035718.1.
DR RefSeq; NP_001319669.1; NM_001339051.1.
DR RefSeq; NP_566854.1; NM_113938.3.
DR AlphaFoldDB; Q9LI61; -.
DR SMR; Q9LI61; -.
DR IntAct; Q9LI61; 7.
DR STRING; 3702.AT3G30390.2; -.
DR PaxDb; Q9LI61; -.
DR PRIDE; Q9LI61; -.
DR ProteomicsDB; 241158; -.
DR EnsemblPlants; AT3G30390.1; AT3G30390.1; AT3G30390.
DR EnsemblPlants; AT3G30390.2; AT3G30390.2; AT3G30390.
DR EnsemblPlants; AT3G30390.3; AT3G30390.3; AT3G30390.
DR GeneID; 822740; -.
DR Gramene; AT3G30390.1; AT3G30390.1; AT3G30390.
DR Gramene; AT3G30390.2; AT3G30390.2; AT3G30390.
DR Gramene; AT3G30390.3; AT3G30390.3; AT3G30390.
DR KEGG; ath:AT3G30390; -.
DR Araport; AT3G30390; -.
DR TAIR; locus:2102926; AT3G30390.
DR eggNOG; KOG1305; Eukaryota.
DR HOGENOM; CLU_034419_2_0_1; -.
DR InParanoid; Q9LI61; -.
DR OMA; KARMQNV; -.
DR OrthoDB; 697331at2759; -.
DR PhylomeDB; Q9LI61; -.
DR PRO; PR:Q9LI61; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LI61; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..460
FT /note="Amino acid transporter AVT6A"
FT /id="PRO_0000440112"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT CONFLICT 345
FT /note="Y -> C (in Ref. 4; BAH20104)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 460 AA; 49517 MW; 71C0DA11E04FE7D0 CRC64;
MTVVGDVAPI PRRNSSTCSN DIAAPLLPEC HGDEVAHDEF NGASFSGAVF NLATTIIGAG
IMALPATMKI LGLGLGITMI VVMAFLTDAS IEFLLRFSKA GKNRSYGGLM GGSFGNPGRI
LLQVAVLVNN IGVLIVYMII IGDVLAGKTE DGIHHFGVLE GWFGHHWWNG RAAILLITTL
GVFAPLACFK RIDSLKFTSA LSVALAVVFL IITAGISIMK LISGGVAMPR LLPDVTDLTS
FWNLFTVVPV LVTAFICHYN VHSIQNELED PSQIRPVVRS ALMLCSSVYI MTSIFGFLLF
GDDTLDDVLA NFDTDLGIPF GSILNDAVRV SYALHLMLVF PIVFYPLRIN IDGLLFPSAR
SLSTSNVRFG CLTAGLISVI FLGANFIPSI WDAFQFTGAT AAVCLGFIFP ASIILKDRHD
KATNRDTTLA IFMIVLAVLS NAIAIYSDAY ALFKKNAPRE
