AVT6C_ARATH
ID AVT6C_ARATH Reviewed; 435 AA.
AC Q9LYM2;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Amino acid transporter AVT6C {ECO:0000305};
DE Short=AtAvt6C {ECO:0000303|PubMed:27925655};
GN Name=AVT6C {ECO:0000303|PubMed:27925655};
GN OrderedLocusNames=At3g56200 {ECO:0000312|Araport:AT3G56200};
GN ORFNames=F18O21_160 {ECO:0000312|EMBL:CAB87419.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27925655; DOI=10.1002/1873-3468.12507;
RA Fujiki Y., Teshima H., Kashiwao S., Kawano-Kawada M., Ohsumi Y.,
RA Kakinuma Y., Sekito T.;
RT "Functional identification of AtAVT3, a family of vacuolar amino acid
RT transporters, in Arabidopsis.";
RL FEBS Lett. 591:5-15(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.6) subfamily.
CC {ECO:0000305}.
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DR EMBL; AL163763; CAB87419.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79493.1; -; Genomic_DNA.
DR EMBL; AY094388; AAM19768.1; -; mRNA.
DR PIR; T47737; T47737.
DR RefSeq; NP_191179.1; NM_115478.7.
DR AlphaFoldDB; Q9LYM2; -.
DR SMR; Q9LYM2; -.
DR IntAct; Q9LYM2; 2.
DR STRING; 3702.AT3G56200.1; -.
DR PaxDb; Q9LYM2; -.
DR PRIDE; Q9LYM2; -.
DR ProteomicsDB; 241160; -.
DR EnsemblPlants; AT3G56200.1; AT3G56200.1; AT3G56200.
DR GeneID; 824786; -.
DR Gramene; AT3G56200.1; AT3G56200.1; AT3G56200.
DR KEGG; ath:AT3G56200; -.
DR Araport; AT3G56200; -.
DR TAIR; locus:2078381; AT3G56200.
DR eggNOG; KOG1305; Eukaryota.
DR HOGENOM; CLU_034419_2_0_1; -.
DR InParanoid; Q9LYM2; -.
DR OMA; DSQMAYT; -.
DR OrthoDB; 697331at2759; -.
DR PhylomeDB; Q9LYM2; -.
DR PRO; PR:Q9LYM2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LYM2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..435
FT /note="Amino acid transporter AVT6C"
FT /id="PRO_0000440114"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 47105 MW; 70B556C3CC3F0E26 CRC64;
MTPQIKTHLL PKQEPSSSEN HGSSTSGIVF NVSTSIIGAG IMSMPAAFKV LGIVPAFLII
TIIAWLSTIS VGFLMKSTLA GESTTYAGVM KESFGKTGSI AVQIATMVAT FGCMIIFSII
IGDVLSGNEN GGPEHIGVLQ EWFGSYWWNT RIFALLFVYG FVLLPLVLRR RVERLAISSA
VSFLLAVLFV VISSVLAISA LVNGQTKNPR LFPELSNGGS FWQLFTASPV IVTAFTFHFN
VHPIGFELKD PLQVIPATKI SVILCAAIYF ATGLFGYLLF GDATMSDILV NFDQSSGSSI
GSLLNDIVRL SYVLHLMLVF PLLNFSLRAN LDELLYPKKP SLEKDTKRFI GLTLALLICC
FLSAIAVPDI WYFFQFMGST ITVSIAFIFP AAIVLRNIHG VSTSREKIVA AIMLVLAVAT
SIIAISTNLY SLAAN
